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EC number: 231-843-4
CAS number: 7758-94-3
No relevant effects
This endpoint is covered by the category approach for soluble iron salts
(please see the section for physical and chemical properties for the
category justification/report format). Testing for this endpoint has
been waived in accordance with column 2 and Annex XI, 1.2 restrictions.
There are no standard long-term terrestrial toxicity tests reported in
the literature, but data on acute effects of soluble iron salts in
irrelevantly high concentrations in food are known from the literature.
Thus these experiments are not relevant for assessment.
Grimes & Jaber (1986) evidenced the absence of acute effects of ferric
sulphate on mortality of Northern bobwhite quail (Colinus virginianus)
exposed to 2'250 mg Fe(+2)/kg bw administered via oral capsules during
14 days. Further data exist with regard to dietary exposure. The same
publication reports the absence of 50 % mortality after 8 day dietary
exposure of the same species up to levels of 5620 mg Fe(+2)/kg bw.
Bantam chickens (Gallus domesticus) showed no effects on growth
or survival following 14 days exposure to 1'000 mg Fe (+2)/kg diet in
addition to harmful cadmium levels (Blalock & Hill 1988). This evidences
the absence of iron toxicity at this level and indicates its potential
to compensate effects of other metals. This is in line with another
study reported from Hill (1979). At 147 mg Fe(+2)/kg diet no effects
have been determined on weight gain following two weeks dietary exposure
of the same species.
The assignment of the 8-day LC50 to a dose above 5000 mg Fe(+2)/kg diet
has been confirmed by a study of the Office of Pesticide Programs (2000)
with Mallard ducks (Anas platyrhynchos).
In conclusion the available data are insufficient for threshold level
derivation but indicate the absence acute toxicity to birds up to levels
of 5 g Fe(+2)/kg diet (acute 8-day NOEC > 5 g Fe(+2)/kg diet).
No assessment of long term toxicity can be based on this experimental
information. Secondary poisoning can be excluded as discussed in the
summary of the section Ecotoxicological information.
Iron species do not exhibit relevant acute avian toxicity. Chronic
toxic effects to birds under environmental conditions seem unlikely.
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