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EC number: 232-304-6
CAS number: 8002-26-4
A complex combination of tall oil rosin and fatty acids derived from acidulation of crude tall oil soap and including that which is further refined. Contains at least 10% rosin.
the purposes of determining a Derived No Effect Level, a conservative
approach is taken in which, as a worst case, the 2-year NOAEL >200
mg/kg/ day is used to represent the toxicity of the whole substance for
repeated dose systemic toxicity in all cases. In the absence of any
findings indicative of reproductive or developmental effects for any of
the substances tested, DNELs for these endpoints cannot be quantified.
No short-term peak exposures to DTO are expected under normal conditions
of use, so long-term DNELs are also protective for short-term exposures.
The substance is not classified as skin irritant, eye irritant or
oral route is not considered for workers, since oral exposure will not
occur during normal handling and use of DTO.
descriptor(s) per endpoint and endpoint-specific DNEL(s)/DMEL(s) for
Most relevant quantitative dose descriptor (appropriate unit)
Corrected dose descriptor (appropriate unit)
Overall AF applied
Repeated dose toxicity sub-acute/ sub-chronic/ chronic
NOAEL >200 mg/kg/d
NOAEL >50 mg/kg/d
NOAEC >177 mg/m3
DN(M)ELs for workers
Most sensitive endpoint
Acute - systemic effects
Acute - local effects
Long-term - systemic effects
Long-term – local effects
For the purposes of determining a Derived No
Effect Level, a conservative approach is taken in which, as a worst
case, the 2-year NOAEL >200 mg/kg/ day is used to represent the toxicity
of the whole substance for repeated dose systemic toxicity. In the
absence of any findings indicative of reproductive or developmental
effects, DNELs for these endpoints cannot be quantified.
No short-term peak exposures to DTO are
expected under normal conditions of use, so long-term DNELs are also
protective for short-term exposures.
DTO does not have any local irritant effects
and is not a skin sensitiser.
is not classified for acute toxicity, irritation, sensitisation,
repeated-dose toxicity, carcinogenicity, mutagenicity, reproductive or
developmental toxicity. Findings in repeated-dose dietary studies in
rats were minor and related mainly to unpalatability of the test diet,
rather than showing evidence of systemic toxicity. However, the
available data have been used to determine indicative long-term DNEL
values, as a worst-case.There were no effects for reproductive or
developmental endpoints; therefore it is not possible to quantify DNELs
for reproductive or developmental toxicity.
DN(M)ELs for the general population
DNEL/DMEL (appropriate unit)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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