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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: limited but acceptable documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973

Materials and methods

Principles of method if other than guideline:
In vivo eye irritation study
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Di(benzothiazol-2-yl) disulphide
EC Number:
204-424-9
EC Name:
Di(benzothiazol-2-yl) disulphide
Cas Number:
120-78-5
Molecular formula:
C14H8N2S4
IUPAC Name:
di(benzothiazol-2-yl) disulphide
Details on test material:
CP 1612

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not required
Duration of treatment / exposure:
24 h
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
6

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24, 48, 72 h
Score:
0.6
Max. score:
110
Reversibility:
fully reversible within: 48 h
Remarks on result:
other: immediate: slight discomfort, 10 min: slight erythema, moderate discharge

Any other information on results incl. tables

Immediate: slight discomfort

10 minutes: slight erythema, moderate discharge

1 hour: slight erythema, moderate discharge

24 hours: slight erythema (mean score 24 h: 2/110)

48 hours: all scored zero

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met