Registration Dossier
Registration Dossier
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EC number: 204-424-9 | CAS number: 120-78-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
Materials and methods
- Principles of method if other than guideline:
- In vivo eye irritation study
- GLP compliance:
- no
Test material
- Reference substance name:
- Di(benzothiazol-2-yl) disulphide
- EC Number:
- 204-424-9
- EC Name:
- Di(benzothiazol-2-yl) disulphide
- Cas Number:
- 120-78-5
- Molecular formula:
- C14H8N2S4
- IUPAC Name:
- di(benzothiazol-2-yl) disulphide
- Details on test material:
- CP 1612
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0.6
- Max. score:
- 110
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: immediate: slight discomfort, 10 min: slight erythema, moderate discharge
Any other information on results incl. tables
Immediate: slight discomfort
10 minutes: slight erythema, moderate discharge
1 hour: slight erythema, moderate discharge
24 hours: slight erythema (mean score 24 h: 2/110)
48 hours: all scored zero
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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