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EC number: 204-424-9
CAS number: 120-78-5
The acute dermal and oral toxicity of the test substance MBTS is very
low, indicated by LD50 values greater than 7940 mg/kg bw. The acute oral
LD50 value in rats is greater than 7940 mg/kg bw (Monsanto Co. 1973) and
the dermal LD50 value in rabbits is greater than 7940 mg/kg bw (Monsanto
Mortality: no mortality occurred during the study
3160 mg/kg: male -, female (0/1), combinded (0/1)
5010 mg/kg: male (0/1), female - , combinded (0/1)
7940 mg/kg: male (0/2), female (0/3), combinded (0/5)
Reduced appetite and activity (one to three days)
Survivors (7 day): viscera appeared normal
Mortality: no death occurred during the study
5010 mg/kg: male 0/1, female -, combined 0/1
7940 mg/kg: male 0/1, female 0/1, combined 0/2
Clinical signs observed: reduced appetite and activity (one to two days)
Gross autopsy (survivors 14 days study termination): viscera appeared
Acute toxicity: oral
The acute oral toxicity of MBTS was evaluated in acute oral toxicity
studies in rats. Although the study results are reliable the test design
of the studies does not comply with the current guidelines.
In an acceptable documented study with Sprague-Dawley Albino rats a 25%
suspension in corn oil of the test substance was administered by gavage
to male and female rats at doses of 3160, 5010 and 7940mg/kg bw. A 7-day
observation period followed administration. No mortality occurred during
the study. An oral LD50 value > 7940 mg/kg bw was suggested. Clinical
signs were observed and included reduced appetite and activity (one to
three days). Autopsy was performed at study termination; viscera of all
animals appeared normal at sacrifice (Monsanto Co. 1973).
In a limited documented acute toxicity study with Sprague-Dawley rats,
an oral LD50 value greater 10000 mg/kg bw is suggested (Monsanto Co.
Acute toxicity: dermal
The acute dermal toxicity of MBTS was evaluated in a limited but
acceptable documented acute dermal toxicity study with New Zealand
Albino rabbits (Monsanto Co. 1973). One male was treated with 5010 mg/kg
bw and one male and one female with 7940 mg/kg bw MBTS (40% test
substance suspension in corn oil) for 24 hours. No mortality occurred
during the study. Clinical signs observed included reduced appetite and
activity (one to two days). Gross autopsy at study termination (14 days
after test substance application) revealed no abnormalities in viscera
in the treated animals. A dermal LD50 value greater than 7940 mg/kg bw
acute dermal and oral toxicity of the test substance MBTS is very low,
indicated by LD50 values greater than 7940 mg/kg bw. No classification
for the endpoints oral and dermal acute toxicity is required according
to the classification criteria of regulation no. 1272/2008 (GHS).
Note: according to
regulation no. 1272/2008 (GHS) (EUH031: contact with acids liberates
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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