Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-424-9
CAS number: 120-78-5
Mortality: no death occured during the study
Clinical signs: no clinical signs were noted in any of the treated
animals or control animals
Body weight gain: maternal body weight gain during day 0 to 14 of
pregnancy was significant reduced in the high dose group (1% MBTS in the
diet) compared to control
Food consumption: no significant differences in food consumption was
observed in treated females compared to control, however the food
consumption was lower in the high dose group compared to control
Pregnancy rate: no significant differences were noted in the pregnancy
rate in treated females compared to control
Table: maternal findings
a: Expressed as mean ± SD
b: non-pregnant rats were excluded
* significant different from control
There were no significant differences in the incidences of pre-and
postimplantation losses, the number of corpora lutea per litter,
implantations per litter and live fetuses per litter, the sex ratio of
live fetuses, the fetuses body weight of both sexes and the placental
Table: Reproductive findings in rats given dietary MBTS
Offspring Morphological findings in fetuses of rats given dietary MBTS
Table: morphological findings in fetuses Dietary level of MBTS (%) 0
0.04 0.2 1
b: b: (No. of corpora lutea minus no.of implantations/ no. of corpora
lutea) X 100. c: (No. of implantations minus no. of live fetuses/ no. of
implantations) X 100. Offspring Morphological findings in fetuses of
rats given dietary MBTS Table: morphological findings in fetuses Dietary
level of MBTS (%) 0 0.04 0.2 1
a: Expressed as mean ± SD b:
b: (No. of corpora lutea minus no.of implantations/ no. of corpora
lutea) X 100.
c: (No. of implantations minus no. of live fetuses/ no. of
implantations) X 100.
Morphological findings in fetuses of rats given dietary MBTS:
No treatment-related effects for external, skeletal and internal
malformation were noted. The incidences of the fetuses and litters that
had skeletal variations or delayed ossifications were not significantly
different between MBTS-treated animals and control group. There was no
significant difference between the MBTS-treated and control group in the
degree of ossification, indicated by the numbers of the caudal vertebrae.
Table: morphological findings in fetuses
Postnatal findings in offspring of rats given dietary MBTS Table:
postnatal findings in offspring ietary level of MBTS (%) 0 0.04 0.2
a: expressed as mean ± SD Postnatal findings in offspring of rats given
dietary MBTS Table: postnatal findings in offspring ietary level of MBTS
(%) 0 0.04 0.2 1
a: expressed as mean ± SD
Note: extra group (number of dams unclear, dams killed on day 21 after
Postnatal findings in offspring of rats given dietary MBTS (extra
group:offspring killed 7 weeks after birth)
No significant differences between the MBTS-treated animals and control
groups were found in the gestation lengh of maternal rats, the numbers
of implantation remnants per litter and live newborns per litter and the
live birth index. The survival rate of the offspring before and after
weaning was very high and almost constant in all groups. Autopsy of the
dead offspring of the MBTS-treated groups revealed no consistent
tendency, and the cause of death remained unclear. The body weights of
offspring for both sexes was not signifcant different between MBTS
treated animals and control up to week 7 (postnatal)
Table: postnatal findings in offspring
b: (No. of live newborns at birth/no. of implantation remnants) X 100.
c (No. of live offspring/ no. of newborns after adjustment of litter
size at birth) X 100.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
På den här webbplatsen används kakor. Syftet är att optimera din upplevelse av den.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again