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EC number: 204-424-9
CAS number: 120-78-5
A study was conducted
according to OECD Guideline for Testing of Chemicals, No. 210 "Fish,
Early-life Stage Toxicity Test" to determine lethal and sub-lethal
effects of the test item MBTS on the early-life stages of Danio rerio (zebrafish).
To achieve this, a limit concentration of the test item in aqueous
solution was prepared using a filtrate at a loading rate of 10 mg test
item/l (mean measured >0.43 µg/L). The test organisms were exposed to
this limit concentration as well as to control without the test item.
During the test period the test solutions were be renewed in a
Newly fertilised eggs of the
test species were exposed to this test concentration until 30 days
post-hatch. Lethal and sub-lethal effects of the test item on eggs,
larvae and juvenile fish were assessed in comparison with control values
to determine the lowest observed effect concentration (LOEC) and the no
observed effect concentration (NOEC). The following biological
parameters were investigated: hatching success; number of larvae
hatching each day; time to start of hatching and end of hatching;
cumulative mortality, post-hatch success (survival); number of deformed
or abnormally appearing larvae; number of organisms exhibiting abnormal
behaviour; length of the surviving fish; wet and dry weight of the
surviving fish. 6 replicates of 20 fertilized eggs per concentration and
control were exposed.
As no chronic toxic effects were observed,
a NOEC of >= 10 mg/L (nominal) equaling >= 0.43 µg/L (mean measured)
and a LOEC of >10 mg/L (nominal) equaling >0.43 µg/L (mean measured)
were determined for MBTS for hatching success, post-hatch success
(survival), number of healthy fish, length of surviving fish, wet and
dry weight of the surviving fish, respectively.
No chronic toxic effect of MBTS to Danio renio in a limit test at a test
item concentration of 10 mg/L (nominal) were observed during the
experimental period of 35 days (ECT 2017).
The derived 35d-NOEC is found to be >= 10 mg/L (nominal) and the
35d-LOEC >10 mg/L (nominal).
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