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EC number: 205-572-7
CAS number: 142-92-7
An Ames test performed with hexyl acetate in S. typhimurium TA98,
TA100, TA102, TA1535 and TA1535 reports an inconsistentlty
positive result in TA102 only, in the absence of metabolic
activation. This result was not replicated in a follow-up study by
the same authors performed in TA102 only. A negative result is
reported in an Ames test performed using the read-across substance
n-butyl acetate; a negative result is also reported in an assay of
clastogenicity in CHL cells with n-butyl acetate.
Justification for selection of genetic toxicity endpoint
A weight of evidence approach is used for this endpoint.
Short description of key information:
Ames tests are available for hexyl acetate and the read-across substance n-butyl acetate; a clastogenicity study in vitro is available for n-butyl acetate.
Endpoint Conclusion: No adverse effect observed (negative)
Following a weight of evidence approach, the results of genotoxicity
studies in vitro do not indicate that hexyl acetate is genotoxic. No
classification is therefore required according to the CLP Regulation.
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