Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-572-7 | CAS number: 142-92-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Data reported January 25, 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Limited methodological detail but sufficient for the purposes of hazard classification
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Remarks:
- conducted prior to adoption of GLP principles
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Hexyl acetate
- EC Number:
- 205-572-7
- EC Name:
- Hexyl acetate
- Cas Number:
- 142-92-7
- Molecular formula:
- C8H16O2
- IUPAC Name:
- hexyl acetate
- Reference substance name:
- acetic acid hexyl ester
- IUPAC Name:
- acetic acid hexyl ester
- Test material form:
- other: clear liquid
- Details on test material:
- No further details
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No additional information available
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- No information provided
- Duration of exposure:
- No information provided
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- Ten rabbits used in total but no breakdown by sex available
- Control animals:
- no
- Details on study design:
- Ten rabbits were exposed by dermal application to 5000 mg/kg bw of hexyl acetate. The rabbits were observed for 14 days following dosing. Mortality and clinical signs were recorded.
- Statistics:
- Not required
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: One death on the day of treatment
- Mortality:
- One rabbit died on day 1.
- Clinical signs:
- other: Prior to death the single decedent animal exhibited signs of sluggishness
- Gross pathology:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal toxicity of hexyl acetate in the rabbit was found to be >5000 mg/kg bw under the conditions of this study.
- Executive summary:
Following dermal exposure to 5000 mg hexyl acetate/kg bw, one of ten rabbits exposed died on Day 1 of the observation period. The decedent developed signs of sluggishness prior to death. The acute dermal toxicity of hexyl acetate in the rabbit was therefore found to be >5000 mg/kg bw under the conditions of this study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
