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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Data reported January 25, 1973
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Limited methodological detail but sufficient for the purposes of hazard classification

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
no
Remarks:
conducted prior to adoption of GLP principles
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Hexyl acetate
EC Number:
205-572-7
EC Name:
Hexyl acetate
Cas Number:
142-92-7
Molecular formula:
C8H16O2
IUPAC Name:
hexyl acetate
Constituent 2
Reference substance name:
acetic acid hexyl ester
IUPAC Name:
acetic acid hexyl ester
Test material form:
other: clear liquid
Details on test material:
No further details

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No additional information available

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
No information provided
Duration of exposure:
No information provided
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
Ten rabbits used in total but no breakdown by sex available
Control animals:
no
Details on study design:
Ten rabbits were exposed by dermal application to 5000 mg/kg bw of hexyl acetate. The rabbits were observed for 14 days following dosing. Mortality and clinical signs were recorded.
Statistics:
Not required

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: One death on the day of treatment
Mortality:
One rabbit died on day 1.
Clinical signs:
Prior to death the single decedent animal exhibited signs of sluggishness
Body weight:
No data
Gross pathology:
No data

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute dermal toxicity of hexyl acetate in the rabbit was found to be >5000 mg/kg bw under the conditions of this study.
Executive summary:

Following dermal exposure to 5000 mg hexyl acetate/kg bw, one of ten rabbits exposed died on Day 1 of the observation period. The decedent developed signs of sluggishness prior to death. The acute dermal toxicity of hexyl acetate in the rabbit was therefore found to be >5000 mg/kg bw under the conditions of this study.