Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-572-7 | CAS number: 142-92-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published screening study for acute oral toxicity; limited methodological detail but sufficient for the purposes of classification
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1973
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Screening study for acute oral toxicity, with LD50 calculation
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- n-hexyl acetate
- IUPAC Name:
- n-hexyl acetate
- Reference substance name:
- acetic acid hexyl ester
- IUPAC Name:
- acetic acid hexyl ester
- Reference substance name:
- Hexyl acetate
- EC Number:
- 205-572-7
- EC Name:
- Hexyl acetate
- Cas Number:
- 142-92-7
- Molecular formula:
- C8H16O2
- IUPAC Name:
- hexyl acetate
- Test material form:
- not specified
- Details on test material:
- No details provided
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Groups of 5 non-fasted Carworth-Wistar male rats, 4 - 5 weeks old and weighing 90 - 120 grams, were administered a single dose of the undiluted test material by gastric intubation. The animals were observed for mortality during a 14-day observation period, and the LD50 was estimated by the Thompson and Weil method.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Animals were administered a single dose of the undiluted test material by gastric intubation. If lesser concentrations were necessary, the test material was diluted as a solution in water or corn oil, or as a suspension in semi-solid agar.
- Doses:
- No details provided.
- No. of animals per sex per dose:
- Groups of five male rats
- Control animals:
- not specified
- Details on study design:
- No details
- Statistics:
- LD50 estimated using Thompson and Weil method
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 41.5 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- > 30.7 - < 56.1
- Remarks on result:
- other: Assuming a specific gravity value of approximately 1 g/mL, the LD50 value is ~41.5 g/kg bw.
- Mortality:
- No information on rat mortality
- Clinical signs:
- other: No information provided for clinical signs
- Gross pathology:
- No information provided in publication
- Other findings:
- Not reported
Any other information on results incl. tables
The acute oral LD50 was found to be 41.5 g/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Assuming density of 1 g/mL; the acute oral LD50 value of 41.5 mL/kg bw is equivalent to 41500 mg/kg bw or 41.5 g/kg bw.
- Executive summary:
Groups of 5 non-fasted Carworth-Wistar male rats, 4 - 5 weeks old and weighing 90 - 120 grams, were administered a single dose of the undiluted test material by gastric intubation. The animals were observed for mortality during a 14-day observation period, and the LD50 was estimated by the Thompson and Weil method. The acute oral median lethal dose is quoted as 41.5 ml/kg bw for rats (confidence limits 30.7 to 56.1 ml/kg bw), equivalent to approximately 41.5 g/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
