Registration Dossier
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EC number: 205-572-7 | CAS number: 142-92-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Data are available for the acute toxicity of hexyl acetate following oral, dermal and inhalation exposure. Low toxicity is demonstrated for all exposure routes.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 41 500 mg/kg bw
- Quality of whole database:
- A screening study provides limited methodological data but is sufficient for the purposes of hazard characterisation and classification.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 3 µg/m³
- Quality of whole database:
- In the acute study the results from the study are expressed in duration of exposure survived at the highest non-adverse concentration but the actual concentration used was not reported . The reliability of using the repeated exposure study to address acute endpoints is reduced because the doses administered wre not selcted to give maximal acute exposures.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Two studies are available and report acute dermal LD50 values of >5000 and >20000 mg/kg bw.
Additional information
The acute oral LD50 of hexyl acetate in the rat is shown to be 41.5 mL/kg bw (~41.5 g/kg bw). Two studies of acute dermal toxicity in the rabbit report LD50 values of >5000 mg/kg bw and >20 mL/kg bw (~20 g/kg bw). No mortality is reported in a screening study in rats exposed for 8 hours to a saturated vapour concentration of hexyl acetate.
Justification for selection of acute toxicity – oral endpoint
Only one study available for this endpoint
Justification for selection of acute toxicity – inhalation endpoint
The repeated exposure study was used as the key indicator of the absence of acute effects. At the maximum atmosphere concentration there were no adverse effects indicative of acute toxicity (or repeated exposure toxicity) observed following exposure to atmospheres with concentrations of 500, 1500 or 3000 ppm.
This was supported by an LC50 determination that indicated no adverse effects were observed in rats exposed at the MTD for 8 hours.
Justification for selection of acute toxicity – dermal endpoint
This study reports a lower LD50 value
Justification for classification or non-classification
The results of acute oral, dermal and inhalation toxicity studies do not trigger the classification of hexyl actetate for acute toxicity according to the CLP Regulation.
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