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EC number: 205-572-7
CAS number: 142-92-7
Data are available for the acute toxicity of hexyl acetate following oral, dermal and inhalation exposure. Low toxicity is demonstrated for all exposure routes.
Effects (acute, transient signs of reduced activity levels, decreased
body weight and feed consumption, signs of upper respiratory tract
irritation in the nasal passages) were only observed in the high- (3000
ppm) and mid-concentration (1500 ppm) group; there was no systemic,
The mean time weighted analytical exposure concentration for the 500 ppm
(2.4 mg/L) group was 548 ppm (2.6 mg/L))
Repeated exposure to n-butyl acetate for 6 hours per day for five days a
week for 13 weeks at concentrations of 500, 1500 or 3000 ppm resulted in
acute, transient signs of reduced activity levels during exposure to
1500 and 3000 ppm. Decreased body weight and feed consumption were noted
for the 1500 and 3000 ppm groups, but there was no systemic or
organ-specific toxicity. Signs of upper respiratory tract irritation
were seen in the nasal passages of 1500 and 3000 ppm animals, but there
was no evidence of pulmonary toxicity.
The effects following the first single exposure were similar to effects
observed in the subsequent days, no specific effects of acute exposure
were identifiable from this data set.
The acute LC50 is therefore estimated to be >3000ppm (15.3 mg/L).
Following dermal exposure to 5000 mg hexyl acetate/kg bw, one of ten
rabbits exposed died on Day 1 of the observation period. The decedent
developed signs of sluggishness prior to death. The acute dermal
toxicity of hexyl acetate in the rabbit was therefore found to be >5000
mg/kg bw under the conditions of this study.
The acute oral LD50 of hexyl acetate in the rat is shown to be 41.5
mL/kg bw (~41.5 g/kg bw). Two studies of acute dermal toxicity in the
rabbit report LD50 values of >5000 mg/kg bw and >20 mL/kg bw (~20 g/kg
bw). Data indicate the acute inhalation LC50 to be >15.3 mg/L.
Justification for selection of acute toxicity – oral endpoint
Only one study available for this endpoint
Justification for selection of acute toxicity – inhalation endpoint
No deaths were observed in a 90-day inhalation toxicity study performed using the read-across substance n-butyl acetate, which used 6-hour daily exposures of up to 3000 ppm (15.3 mg/L; 15300 mg/m3). This study is supported by the results of a screening study performed using an 8-hour exposure to hexyl acetate at the saturated vapour concentration (calculated to be 1426 ppm, 9.04 mg/L or 9040 mg/m3). The data are therefore consistent in demonstrating a very low potential for acute inhalation toxicity.
Justification for selection of acute toxicity – dermal endpoint
This study reports a lower LD50 value
The results of acute oral, dermal and inhalation toxicity studies show
very low toxicity and do not trigger the classification of hexyl acetate
for acute toxicity according to the CLP Regulation.
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