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EC number: 205-572-7
CAS number: 142-92-7
- overall time-weighted average analytical concentrations:
548.4; 1487.5, 3009.6 ppm for males
547.9, 1487.6, 3008.8 ppm for females
- target analytical concentration for the 500 ppm group was
increased to 550 ppm to ensure that exposure concentration was at
least 500 ppm at all locations of the eposure chamber
Male and female Sprague-Dawley rats (15 animals/sex/dose group)
were exposed to nominal concentrations of 0, 500, 1500 or 3000 ppm
of n-butyl acetate for 6 hours per day, 5 days per week for 13
consecutive weeks. The time-weighted average analytical
concentrations were within 10% of the target concentrations.
Transient signs of sedation were observed during exposure
to the 1500 and 3000 ppm concentrations. Body weights were
significantly reduced in the mid and high concentration
groups. Feed consumption was significantly lower in
the 1500 and 3000 ppm group in comparison to the control group.
Organ weights affected: weights of liver, kidneys and
spleen were significantly lower for the males of the highest
concentration goup. Testes and adrenal gland weights for the mid
and high concentration groups and the lung weights for the 3000
ppm males were significantly higher than for the control group.
Additionally, effects on the stomach (probably stress related) and
pulmonary system were observed: Females of the highest
concentration group showed signs of irritation of the glandular
stomach and necrosis in the non-glandular stomach. Some rats of
the 1500 and 3000 ppm group showed degeneration of the olfactory
epithelium along the dorsal medial meatus and ethmotubinates of
the nasal passages. The severity was mild to moderate for the 3000
ppm group and minimal to mild for the 1500 ppm group. There was no
systemic, organ specific toxicity. The no-observed-adverse-effect
concentration (NOAEC) for this study is 500 ppm (2.4 mg/L).
Long term local respiratory tract irritation was also apparent at
the two higher dose levels in this study but no local effects were
identified in the 500 ppm (NOAEC) group.
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