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EC number: 609-530-2
CAS number: 38172-91-7
Viability / Mortality
No deaths occurred during the study period.
No symptoms of local toxicity at the ears of the animals and no systemic
findings were observed during the study period.
The body weight of the animals, recorded prior to the first application
and prior to treatment with 3HTdR, was within the range commonly
recorded for animals of this strain and age.
Lymph Node Weights and Cell Counts
The measured lymph node weights and –cell counts of all animals treated
were recorded after sacrifice. A statistically significant or
biologically relevant increase in lymph node weights was not observed in
any of the test item treated groups in comparison to the vehicle control
group. For BALB/c mice, a cutoff-value for the lymph node cell count
index of 1.55 was reported for a positive response. The indices
determined for the lymph node cell count did not exceed this threshold.
The measured ear weights of all animals treated were recorded after
sacrifice. A statistically significant or biologically relevant increase
in ear weights was not observed in any treated group in comparison to
the vehicle control group.
For BALB/c mice, a threshold for the ear weight index of 1.1 was
reported for a positive response. The indices determined for the lymph
node cell count did not exceed this threshold. Furthermore, according to
OECD guideline 429, an increase in ear weight exceeding the threshold
value of 25% was considered to be indicative for excessive local skin
irritation. This threshold was not exceeded in any test item treated
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