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Diss Factsheets
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EC number: 609-530-2 | CAS number: 38172-91-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.115 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Dose descriptor starting point:
- NOAEC
- Value:
- 52.89 mg/m³
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 52.89 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- NOAEL
- Value:
- 30 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 150 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - workers
Worker:
Based on the available data 2-Propyn-1-ol, compd. with methyloxirane (Golpanol PAP), has to be considered as harmful if swallowed (R22 according to Directive 67/548/EEC annex VI; Cat. 4 according to EC/1271/2008) and as posing the risk of serious damage to the eye (R41; Cat. 1), respectively.
The primary routes of anticipated industrial and professional exposure are via inhalation and skin contact. In industrial settings, ingestion is not an anticipated route of exposure, but has to be considered for the general population (see below).
Inhalation long-term exposure – systemic effects:
The NOAEL from an oral OECD Guideline 408 study (BASF, 2017) was identified as the appropriate starting point for DNEL derivation for long-term exposure following inhalation. The NOAEL for systemic toxicity was at 30 mg/kg bw/day.
This point of departure was modified to get the corrected starting point for DNEL derivation. As a first step, route-to-route extrapolation was performed as recommended in the "Guidance on information requirements and chemical safety assessment, Chapter R.8, p. 26 f.:
The oral rat NOAEL was converted into the inhalative human NOAEC corrected for differences between the 8-hour standard inhalation volume of rats versus humans, and for differences between the 8-hour inhalation volume of workers in rest versus workers in light activity, by multiplying with the corresponding factors (x 1/0.38 m³/kg/d x 6.7 m³/10 m³). The resulting corrected starting point for inhalation DNEL derivation for workers is equal to 52.89 mg/m³.
For DNEL derivation, the following assessment factors (AF) were applied to the corrected starting point:
- Interspecies factor: 1
Besides the applied allometric scaling factors no additional interspecies factor for remaining differences has been used based on the fact that concerning inhalation, rodents like the rat are in general more sensitive compared to human as the rat's ventilation frequency is higher. Also anatomical differences as well as air flow patterns between rodents and humans have to be taken into account.
- Remaining differences: 2.5
Standard factor as outlined in REACh Guidance document R.8
- Intraspecies factor: 5
Standard factor as outlined in REACh Guidance document R.8
- Exposure duration: 2
Standard factor as outlined in REACh Guidance document R.8
- Dose-response: 1
Total AF = 1 x 2.5 x 5 x 2 x 1 = 25
Based on this calculation the resulting DNEL is 2.115 mg/m3
Dermal long-term exposure – systemic effects:
The NOAEL from an oral OECD Guideline 408 study (BASF, 2017) was identified as the appropriate starting point for DNEL derivation for long-term exposure following dermal uptake. The NOAEL for systemic toxicity was at 30 mg/kg bw/day.
This point of departure was modified to get the corrected starting point for DNEL derivation. As the acute data shows that acute dermal toxicity is considerably lower than acute oral toxicity (no mortality at 2000 mg/kg after dermal exposure vs. mortality at 464 mg/kg after oral exposure) and based on the toxicokinetic assessment which came to the conclusion that dermal absorption is negligible, the NOAEL can be corrected at least by a factor of 5 based on the available data which resulted in a corrected starting point for DNEL derivation for worker of 150 mg/kg bw/day.
For DNEL derivation, the following assessment factors (AF) were applied to the corrected starting point:
- Interspecies factor: 4
Recommended for the rat in REACh Guidance document R.8 for allometric scaling
- Intraspecies factor: 5
Standard factor as outlined in REACh Guidance document R.8
- Exposure duration: 2
Standard factor as outlined in REACh Guidance document R.8
- Dose-response: 1
- Remaining differences: 2.5
Standard factor as outlined in REACh Guidance document R.8
Total AF = 4 x 5 x 2 x 1 x 2.5 = 100
Based on this calculation the resulting DNEL is 1.5 mg/kg bw/day.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.521 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Dose descriptor starting point:
- NOAEC
- Value:
- 26.086 mg/m³
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 26.086 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.75 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Dose descriptor starting point:
- NOAEL
- Value:
- 30 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 150 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.15 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Dose descriptor starting point:
- NOAEL
- Value:
- 30 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 30 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
- Explanation for the modification of the dose descriptor starting point:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
- Justification:
- see discussion
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - General Population
Consumer
Based on the available data 2-Propyn-1-ol, compd. with methyloxirane (Golpanol PAP), has to be considered as harmful if swallowed (R22 according to Directive 67/548/EEC annex VI; Cat. 4 according to EC/1271/2008) and as posing the risk of serious damage to the eye (R41; Cat. 1), respectively.
For the general population, all three possible routes of exposure (oral, dermal, inhalation) have to be taken into account.
Inhalation long-term exposure – systemic effects:
The NOAEL from an oral OECD Guideline 408 study (BASF, 2017) was identified as the appropriate starting point for DNEL derivation for long-term exposure following inhalation. The NOAEL for systemic toxicity was at 30 mg/kg bw/day.
This point of departure was modified to get the correct starting point for DNEL derivation. As a first step, route-to-route extrapolation was performed as recommended in the "Guidance on information requirements and chemical safety assessment, Chapter R.8, p. 26 f.:
The oral rat NOAEL was converted into the inhalative human NOAEC corrected for differences between the 24-hour standard inhalation volume of rats versus humans by multiplying with the corresponding factor (x 1/1.15 m³/kg/d). The resulting corrected starting point for inhalation DNEL derivation for the general population is equal to 26.086 mg/m³.
For DNEL derivation, the following assessment factors (AF) were applied to the corrected starting point:
- Interspecies factor: 1
Besides the applied allometric scaling factors no additional interspecies factor for remaining differences has been used based on the fact that concerning inhalation, rodents like the rat are in general more sensitive compared to human as the rat's ventilation frequency is higher. Also anatomical differences as well as air flow patterns between rodents and humans have to be taken into account.
- Remaining differences: 2.5
Standard factor as outlined in REACh Guidance document R.8
- Intraspecies factor: 10
Standard factor as outlined in REACh Guidance document R.8
- Exposure duration: 2
Standard factor as outlined in REACh Guidance document R.8
- Dose-response: 1
Total AF = 1 x 2.5 x 10 x 2 x 1 = 50
Based on this calculation the resulting DNEL is 0.521 mg/m3.
Dermal long-term exposure – systemic effects:
The NOAEL from an oral OECD Guideline 408 study (BASF, 2017) was identified as the appropriate starting point for DNEL derivation for long-term exposure following dermal uptake. The NOAEL for systemic toxicity was at 30 mg/kg bw/day.
This point of departure was modified to get the corrected starting point for DNEL derivation. As the acute data shows that acute dermal toxicity is considerably lower than acute oral toxicity (no mortality at 2000 mg/kg after dermal exposure vs. mortality at 464 mg/kg after oral exposure) and based on the toxicokinetic assessment which came to the conclusion that dermal absorption is negligible, the NOAEL can be corrected at least by a factor of 5 based on the available data which resulted in a corrected starting point for DNEL derivation for the general population of 150 mg/kg bw/day.
The NOAEL of 150 mg/kg bw/day was considered appropriate as point of departure for DNEL derivation. Subsequently, the following assessment factors are taken into account for the final DNEL calculation for the oral route: interspecies differences (4), remaining differences (1), intraspecies differences (10), exposure duration (2) (AF = 4 x 10 x 2 x 1 x 2.5 = 200
As a consequence, the resulting DNEL for long-term oral local and systemic effects is 0.75 mg/kg bw/d for the general population.
For DNEL derivation, the following assessment factors (AF) were applied to the corrected starting point:
- Interspecies factor: 4
Recommended for the rat in REACh Guidance document R.8 for allometric scaling
- Intraspecies factor: 10
Standard factor as outlined in REACh Guidance document R.8
- Exposure duration: 2
Standard factor as outlined in REACh Guidance document R.8
- Dose-response: 1
- Remaining differences: 2.5
Standard factor as outlined in REACh Guidance document R.8
Oral short-term –systemic effects:
The long-term oral DNEL for systemic effects will also be sufficiently protective for short-term oral systemic effects. Furthermore, the hazard is considered low and based on the available data calculation of a meaningful DNEL is not possible.
Oral long-term exposure – systemic effects:
The NOAEL from an oral OECD Guideline 408 study (BASF, 2017) was identified as the appropriate starting point for DNEL derivation for long-term exposure following oral uptake. The NOAEL for systemic toxicity was at 30 mg/kg bw/day.
The NOAEL of 30 mg/kg bw/day was considered appropriate as point of departure for DNEL derivation. Subsequently, the following assessment factors are taken into account for the final DNEL calculation for the oral route: interspecies differences (4), remaining differences (1), intraspecies differences (10), exposure duration (2) (AF = 4 x 10 x 2 x 1 x 2.5 = 200.
As a consequence, the resulting DNEL for long-term oral local and systemic effects is 0.15 mg/kg bw/d for the general population.
For DNEL derivation, the following assessment factors (AF) were applied to the corrected starting point:
- Interspecies factor: 4
Recommended for the rat in REACh Guidance document R.8 for allometric scaling
- Intraspecies factor: 10
Standard factor as outlined in REACh Guidance document R.8
- Exposure duration: 2
Standard factor as outlined in REACh Guidance document R.8
- Dose-response: 1
- Remaining differences: 2.5
Standard factor as outlined in REACh Guidance document R.8
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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