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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
GLP compliance:
yes (incl. certificate)
Analytical monitoring:
yes
Details on sampling:
The buffer solutions were diluted with water to adjust the appropriate buffer concentration. 100 mg test substance were dissolved in 100 ml buffer solution of the pH stated. The solutions were filled in vials and thermostated at the temperature stated. After a certain time interval aliquots of the samples were injected.
Buffers:
phosphate/disodium hydrogenphosphate
Positive controls:
no
Negative controls:
no
Preliminary study:
The test substance is stable at pH 1.3 (37°C) and pH 4,7 and 9 (50°C). As the data demonstrate no significant hydrolysis can be observed under the pretesting conditions. No further tests were carried out.
Transformation products:
no
% Recovery:
ca. 100
pH:
1.3
Temp.:
37 °C
Duration:
ca. 7 d
% Recovery:
ca. 100
pH:
4
Temp.:
50 °C
Duration:
ca. 7 d
% Recovery:
ca. 100
pH:
7
Temp.:
50 °C
Duration:
ca. 7 d
% Recovery:
ca. 100
pH:
9
Temp.:
50 °C
Duration:
ca. 7 d
Key result
pH:
1.3
Temp.:
37 °C
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
4
Temp.:
50 °C
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
7
Temp.:
50 °C
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
9
Temp.:
50 °C
Remarks on result:
hydrolytically stable based on preliminary test
Validity criteria fulfilled:
not specified

Description of key information

The substance can be considered as hydrolytically stable.

Key value for chemical safety assessment

Additional information

The hydrolysis of ‘2-Propyn-1-ol, compound with methyloxirane’ was investigated under GLP conditions according to OECD Guideline 111 [BASF AG, 1999]. The test was performed at pH 4.0, 7.0 and 9.0 in sterile buffer solutions at a temperature of 50°C. After 7 days of incubation, the recovery rate was 100%. Therefore, the substance can be considered as hydrolytically stable.