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EC number: 609-530-2
CAS number: 38172-91-7
The severity of substance induced eye
effects was quantified for each time point using the following values:
0 = none
0 = normal
1 = very slight
1 = slight
1 = circum-corneal injection
2 = well-defined
2 = iritis
3 = moderate to severe
3 = severe
4 = severe to very severe
The irritation scores were calculated as
mean of the single values of the time points 24 h, 48 h and 72 h and all
One male animal showed contracted pupils
starting 48 hours after application until day 21. Eight days after
application of the test substance this animal also developed small
retractions in the eyelid, loss of corneal tissue and suppuration. These
effects persisted unchanged until day 21. Furthermore this animal showed
marginal vascularization of the cornea on day 21 while the second male
did not show any of these effects at any time point. The female
developed loss of corneal tissue and contracted pupils only 48 hours
after application of the test substance. These effects were fully
reversible within 24 hours.
Based on the irreversible effects in one animal
the test substance hold the risk of serious eye damage.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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