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Environmental fate & pathways

Adsorption / desorption

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Reference
Endpoint:
adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC estimation method
Media:
soil
Radiolabelling:
no
Details on study design: HPLC method:
The substance was separated by liquid chromatography on a cyanopropyl phase under isocratic conditions. The detector measures absorption of UV light (diode array detector). The retention time thus determined is converted into the corresponding k' value. The dead time for the column is determined with nitrate.
The test substance was dissolved in methanol (10,2 mg in 10 ml), diluted tenfold with water (0.1 ml to 1.0 ml) and chromatographed twice under conditions identical to those for the reference substances.

INSTRUMENT:
HP 1090 liquid chromatograph (HewlettPackard)

STATIONARY PHASE:
125 mm x 4 mm, cyanopropyl, particle diameter 5 µm (LiChrospher 100 CN, LiChroCART 125-4, Merck, Darmstadt)

ELUENT:
98 % vol.: water, pH = 7.1
2 % vol.: acetonitrile

FLOW RATE:
1 ml/min

VOLUME INJECTED:
100 µl

DETECTION:
UV (simultaneous at 200 nm, 205 nm and 210 nm)
Type:
log Koc
Value:
< 1.25

Description of key information

Adsorption to the solid soil phase is not expected.

Key value for chemical safety assessment

Additional information

Based on the results of an HPLC measurement according to OECD Guideline 121, the log Koc of ‘2-Propyn-1-ol, compound with methyloxirane’ was estimated to be < 1.25 [BASF AG, 1999]. This indicates that the test substance will not bind to soils and sediments.