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EC number: 203-004-2
CAS number: 102-08-9
The objective of this study was to
evaluate the potential toxicity of the test item,
1,3-Diphenyl-2-thiourea, following a single dermal application to rats.
This study was conductedaccording to
OECD (No. 402, 24th February 1987) and EC (No. 440/2008, Part B.3, 30
May 2008) guidelines, and in compliance with the principles of Good
The test item,
1,3-Diphenyl-2-thiourea,was applied in its original form to the skin of
five female then five male Sprague-Dawley rats at the dose-level of 2000
mg/kg. The application site was covered by a semi-occlusive dressing for
Each animal was observed at least once
a day for mortality and clinical signs for 15 days. From day 2, any
local reactions at the treatment site were also noted. Body weight was
recorded on day 1 and then on days 8 and 15.
On completion of the observation
period, the animals were sacrificed and then submitted for a macroscopic post-mortem
examination. No tissues were preserved.
No unscheduled deaths occurred during
No clinical signs indicative of
systemic toxicity were observed in any animals.
Very slight erythema was recorded at
the application site of 1/5 females from days 11 to 13. No cutaneous
reactions were observed in males.
weight gain was recorded in the most of animals.
No macroscopic changes were seen at
The dermal LD50of the test
item, 1,3-Diphenyl-2-thiourea, was higher than 2000 mg/kg in rats.
Therefore, the test item is not
classified as harmful or toxic by dermal route according to the criteria
of CLP Regulation.
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