Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-004-2 | CAS number: 102-08-9
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: 1a titration method -- GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- GLP compliance:
- yes (incl. QA statement)
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- ca. 11.603
- Temp.:
- 20.8 °C
- No.:
- #2
- pKa:
- ca. 11.95
- Temp.:
- 20.8 °C
- Conclusions:
- Two pKa values were determinated on DPTU :
pKa1 = 11.603 at 20.8 +/- 0.4 °C
pKa2 = 11.950 at 20.8 +/- 0.4 °C - Executive summary:
The Dissociation Constants in Water (Spectrophotometric Method) of the test item N,N’-Diphenyl thiourea (DPTU) was studied according to the OECD guideline 112. Measurements were performed at a temperature of 20.8 +/- 0.4 °C.
Two pKa values were determinated :
pKa1 = 11.603 at 20.8 +/- 0.4 °C
pKa2 = 11.950 at 20.8 +/- 0.4 °C
Reference
Description of key information
Two pKa values were determinated on DPTU :
pKa1 = 11.603 at 20.8 +/- 0.4 °C
pKa2 = 11.950 at 20.8 +/- 0.4 °C
Key value for chemical safety assessment
- pKa at 20°C:
- 11.77
Additional information
The Dissociation Constants in Water (Spectrophotometric Method) of the test item N,N’-Diphenyl thiourea (DPTU) was studied according to the OECD guideline 112. Measurements were performed at a temperature of 20.8 +/- 0.4 °C.
Two pKa values were determinated :
pKa1 = 11.603 at 20.8 +/- 0.4 °C
pKa2 = 11.950 at 20.8 +/- 0.4 °C
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
