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EC number: 203-004-2
CAS number: 102-08-9
derivatives in rubber products may induce contact sensitization and
dermatitis. Sensitization is most often from neoprene rubber, but the
multitude of possible sensitizing
products has remained poorly characterized.
The aim of
this study was to collect information on the occurrence of
thiourea-related contact allergy
and to show novel sources of sensitization.
mixture of dibutyl-, diethyl-, and diphenylthiourea was included in
patch test baseline
series in five Finnish dermatology clinics during 2002–2007. In
addition, an extended series of
rubber chemicals was tested in patients with suspected rubber allergy.
Sources of sensitization to thioureas
were analysed in sensitized patients.
mix yielded positive patch test reactions in 59 of 15 100 patients
(0.39%); 33/59 patients
were also tested with individual rubber chemicals. Diethylthiourea was
positive in 24/33, diphenylthiourea
in 5, and dibutylthiourea in 1 patient. The most common sources of
neoprene-containing orthopaedic braces, sports equipment, and foot wear.
sources of sensitization to thiourea chemicals were detected in most
cases. These sources
comprise a heterogenous group of products extending from orthopaedic
materials to sports equipment.
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