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EC number: 203-004-2
CAS number: 102-08-9
Definitive test - Percentage of Daphnia magna immobilisation
Dissolved O2 and pH measured at the beginning and at the end (48h) of the exposition
Nominal concentration mg/L
Dissolved O2 (mg/L)
Nominal and measured concentrations of the test item at the beginning and at the end of the exposure period
Measured in solutions
Extrapolated* Initial (mg/l)
< QL: concentration lower than the Quantification Limit of the analytical method (0.15mg/L).
< DL: concentration lower than the Quantification Limit of the analytical method (0.045mg/L).
* Concentrations calculated using geometric mean
According to OECD guidance document on aquatic toxicity testing of difficult substances and mixtures
- For static tests, where the concentrations remain within 80-120% of nominal, the effect concentrations can be expressed relative to nominal or measured concentrations;
- For static tests, where the concentrations do not remain within 80-120% of nominal, the effect concentrations could be determined and expressed relative to the geometric mean of the measured concentrations.
As the ratio is lower than 80% for some final concentrations, extrapolated concentrations are used for the calculation of effective concentrations
The acute toxicity (inhibition of mobility) of the test item N,N’-DIPHENYL THIOUREA for a duration of 48 hours was assessed according to the OECD Guideline 202 under GLP. Daphnia magna were exposed under static conditions to a range of concentrations of N,N’-DIPHENYL THIOUREA dissolved in dilution water. The toxic effect measured during the assay was the inhibition of mobility over time periods of 24 and 48 hours.
The concentration of test item causing a 50% reduction in mobility (EC50) was estimated as follows (geometric mean of measured concentration):
EC50-48h = 10.2 mg/L
The acute toxicity was assessed according to the OECD Guideline 202. 48h-EC50 = 10.2 mg/L
48h-EC50 = 10.2 mg/L
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