Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- Spider silk proteins have a relative low log Pow value (ca. 1), indicating that they have no bioaccumulation potential and can be anticipated to be readily biodegradable.
Degradation products of spider silk protein are primarily peptides and amino acids, subsequently degraded to carbon dioxide and water which cause no harm to nature.
Thus, systemic availability of spider silk by aquatic organism following exposure at occupational exposure levels is without toxicological significance. Degradation products of spider silk proteins like peptides and amino acids are irreplaceable nutritional components for aquatic organism.
In conclusion aquatic toxicity testing of recombinant eADF4(C48-CS25C) protein from E. Coli (K12 HMS174(DE3)-plasmid pAMS029) fermentation and subsequent purification is considered as not scientifically (see attached justification).
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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