[No public or meaningful name is available]

Adsorption / desorption

Administrative data

Endpoint:

adsorption / desorption: screening

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance has a low octanol water partition coefficient and the adsorption potential of this substance is related to this parameter

the study does not need to be conducted because the substance and its relevant degradation products decompose rapidly

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2021-08-31 - 2021-10-07

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Partition coefficient type:

octanol-water

Key result

Type:

log Pow

Partition coefficient:

ca. 1

Temp.:

20 °C

pH:

7

Conclusions:

With the values of the water solubility (< 5.5 mg/L) and the estimated solubility in octanol from this preliminary test (< 43 mg/L), the partition coefficient could be calculated to be approx. 8 (= log POW ~ 1) at room temperature. However, it was not possible to determine an exact value for neither the water solubility nor the 1-octanol solubility. Therefore, the real log POW can be higher or lower than the calculated result with the limit values. Consequently, no partition coefficient is reported.

Executive summary:

For the determination of the partition coefficient three separate procedures can be performed: the shake flask method, the high performance liquid chromatography (HPLC) method and the slow stirring method. The first method is applicable when the log POW value falls within the range -2 to 4, the second within the range 0 to 6 and the last for highly hydrophobic substances (log Pow values > 5). Before carrying out either of the experimental procedures a preliminary estimate of the partition coefficient should first be obtained.

As no appropriate analytical method was found, only the result of the preliminary test is presented.

The partition coefficient of the test item was estimated by performance of preliminary tests and using the equation:

Pow = Coctanol/Cwater

For the preliminary test of the 1-octanol solubility increasing volumes of n-octanol were added to an amount of the test item. After each addition of n-octanol the mixtures were stirred for at least 40 minutes and visually checked for any unsolved particles.

The preliminary test at room temperature showed, that the octanol solubility of the test item is < 42 mg/L.

With the values of the water solubility estimated in project CSL-21-1014.02 (< 5.5 mg/L) and the estimated solubility in octanol from this preliminary test (< 43 mg/L), the partition coefficient could be calculated to be approx. 8 (= log POW ~ 1) at room temperature. However, it was not possible to determine an exact value for neither the water solubility nor the 1-octanol solubility. Therefore, the real log POW can be higher or lower than the calculated result with the limit values. Consequently, no partition coefficient is reported.