[No public or meaningful name is available]

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is highly insoluble in water, hence indicating that aquatic toxicity is unlikely to occur

the study does not need to be conducted because the substance is unlikely to cross biological membranes, hence indicating that aquatic toxicity is unlikely to occur

Justification for type of information:

Spider silk proteins have a relative low log Pow value (ca. 1: low lipophilicity), indicating that they have no bioaccumulation potential and can be anticipated to be readily biodegradable.
Degradation products of spider silk protein are primarily peptides and amino acids, subsequently degraded to carbon dioxide and water which cause no harm to nature.
Thus, systemic availability of recombinant spider silk proteine by aquatic organism following exposure at occupational exposure levels is without toxicological significance. Degradation products of spider silk proteins like peptides and amino acids are irreplaceable nutritional components for aquatic organism. Spider silk proteins are not water-soluble, thus, bioavailability of the protein itself cannot be expected in the aquatic (see attached justification).