Registration Dossier
Registration Dossier
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EC number: 411-760-1 | CAS number: 116633-53-5 COMMERCIAL DRAGON II
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993
- Reliability:
- 1 (reliable without restriction)
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- not specified
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Test type:
- other: Annex V
- Limit test:
- yes
Test material
- Reference substance name:
- Bis(N,N',N''-trimethyl-1,4,7-triazacyclononane)-trioxo-dimanganese (IV) di(hexafluorophosphate)monohydrate
- EC Number:
- 411-760-1
- EC Name:
- Bis(N,N',N''-trimethyl-1,4,7-triazacyclononane)-trioxo-dimanganese (IV) di(hexafluorophosphate)monohydrate
- Cas Number:
- 116633-53-5
- Molecular formula:
- C18 H42 Mn2 N6 O3 . 2 F6 P
- IUPAC Name:
- dimanganese(4+) bis(1,4,7-trimethyl-1,4,7-triazonane) bis(hexafluoro-λ⁵-phosphanuide) hydrate trioxidandiide
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: distilled water
- Details on dermal exposure:
- no data
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 female and 5 male rats per dose
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
- Preliminary study:
- no data
- Mortality:
- No deaths
- Clinical signs:
- other: There was no irritation or other dermal changes at the application sites. There were no signs of systemic reaction to treatment.
- Gross pathology:
- Post-mortem examination of all rats killed on Day 15 revealed no macroscopic abnormalities.
- Other findings:
- no data
Any other information on results incl. tables
SIGNS OF TOXICITY
LOCAL: There was no irritation or other dermal changes at the application sites.
SYSTEMIC: There were no signs of systemic reaction to treatment.
EFFECTS IN ORGANS: Post-mortem examination of all rats killed on Day 15 revealed no macroscopic abnormalities.
|
Dose |
Number of animals |
Number of death |
Female |
2000 |
5 |
0 |
Male |
2000 |
5 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- relatively harmless
- Remarks:
- Migrated information ? Criteria used for interpretation of results: EU
- Conclusions:
- Dermal LD50:>2000mg/kg in a rat
- Executive summary:
Dermal LD50: > 2000mg/kg in a rat
SIGNS OF TOXICITY
LOCAL: There was no irritation or other dermal changes at the application sites.
SYSTEMIC: There were no signs of systemic reaction to treatment.
EFFECTS IN ORGANS: Post-mortem examination of all rats killed on Day 15 revealed no macroscopic abnormalities.
Dose
Number of animals
Number of
death
Female
2000
5
0
Male
2000
5
0
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