Bis(N,N',N''-trimethyl-1,4,7-triazacyclononane)-trioxo-dimanganese (IV) di(hexafluorophosphate)monohydrate

Hydrolysis

Administrative data

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1993

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: no data on GLP

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1993

Report date:

1993

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)

Version / remarks:

Commission Directive 84/449/EEC, C.10.

Deviations:

not specified

Principles of method if other than guideline:

no data

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Bis(N,N',N''-trimethyl-1,4,7-triazacyclononane)-trioxo-dimanganese (IV) di(hexafluorophosphate)monohydrate

EC Number:

411-760-1

EC Name:

Bis(N,N',N''-trimethyl-1,4,7-triazacyclononane)-trioxo-dimanganese (IV) di(hexafluorophosphate)monohydrate

Cas Number:

116633-53-5

Molecular formula:

C18 H42 Mn2 N6 O3 . 2 F6 P

IUPAC Name:

dimanganese(4+) bis(1,4,7-trimethyl-1,4,7-triazonane) bis(hexafluoro-λ⁵-phosphanuide) hydrate trioxidandiide

Details on test material:

no data

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
no data

Radiolabelling:

not specified

Study design

Analytical monitoring:

not specified

Details on sampling:

no data

Buffers:

citrate buffer (according to study KE930222)

Estimation method (if used):

no data

Details on test conditions:

no data

Duration of test

Duration of test 1

Duration:

5 d

pH:

4

Initial conc. measured:

ca. 1 500 µg/L

Duration of test 2

Duration:

5 d

pH:

7

Initial conc. measured:

ca. 1 500 µg/L

Duration of test 3

Duration:

5 d

pH:

9

Initial conc. measured:

1 500 µg/L

Number of replicates:

no data

Statistical methods:

no data

Results and discussion

Preliminary study:

no data

Test performance:

no data

Transformation products:

not specified

Details on hydrolysis and appearance of transformation product(s):

Under the test conditions the substance was found to undergo significant hydrolysis at pH4 but no hydrolysis at pH7 and 9. The results indicate that at 25 degr C Commercial Dragon possesses a half-life of between 1 day and 1 year at pH 4 and greater than 1 year at pH 7 and 9.

Other kinetic parameters:

no data

Details on results:

Under the test conditions the substance was found to undergo significant hydrolysis at pH4 but no hydrolysis at pH7 and 9. The results indicate that at 25 degr C Commercial Dragon possesses a half-life of between 1 day and 1 year at pH 4 and greater than 1 year at pH 7 and 9.

Any other information on results incl. tables

Under the test conditions the substance was found to undergo significant hydrolysis at pH4 but no hydrolysis at pH7 and 9.

pH	T in Celsius	K-value in s-1	t 1/2- value in h
4	25		<8760
7	25		>8760
9	25		>8760

Applicant's summary and conclusion

Validity criteria fulfilled:

not specified

Conclusions:

It was suggested that the loss of test substance observed at pH 4 may be due to chelation of the citrate anion with the manganese complex, and not by a hydrolysis mechanism. Therefore the pH 4 hydrolysis test was repeated using only hydrochloric acid to adjust pH (study number KE930222).

Executive summary:

Under the test conditions the substance was found to undergo significant hydrolysis at pH4 but no hydrolysis at pH7 and 9. The results indicate that at 25 deg C the substance possesses a half-life of between 1 day and 1 year at pH4 and greater than 1 year at pH7 and 9. It was suggested that the loss of test substance observed at pH4 may be due to chelation of the citrate anion with the metal complex, and not by a hydrolysis mechanism. Therefore, the pH4 hydrolysis test will be repeated using only hydrochloric acid to adjust the pH. This work will be issued in a separate report.