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EC number: 620-056-5 | CAS number: 874195-61-6
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 Mar 2010 - 16 Jun 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Hess. Ministerium für Umwelt, Energie, Landwirtschaft und Verbraucherschutz, Mainzer Straße 80, D-65189 Wiesbaden
- Type of method:
- flask method
- Water solubility:
- 41 mg/L
- Temp.:
- 20 °C
- pH:
- 6.8
- Water solubility:
- 36 mg/L
- Temp.:
- 20 °C
- pH:
- 4
- Water solubility:
- 33 mg/L
- Temp.:
- 20 °C
- pH:
- 7
- Water solubility:
- 34 mg/L
- Temp.:
- 20 °C
- pH:
- 9
Reference
Results
Preliminary estimation
The solubility of the test item in four test solutions; distilled water, buffer at pH 4, buffer at pH 4 and buffer at pH 9 was found to be between 20 mg/L and 100 mg/L. Therefore the solubility had to be determined by the “flask method”.
Pre-tests in Distilled Water and in Buffers at pH 4, pH 7 and pH 9 according to the Flask Method
The pre-tests indicated solubility in distilled water and at pH 4, pH 7 and pH 9 above 10 mg/L. No significant pH dependency was observed. Therefore, for the main tests the water solubility by the flask method was only determined in distilled water.
Table: Results of the HPLC measurements
Solubility in |
Solubility |
measured pH |
Distilled Water |
41 mg/L |
6.99 |
Buffer pH 4 |
36 mg/L |
4.01 |
Buffer pH 7 |
33 mg/L |
7.01 |
Buffer pH 9 |
34 mg/L |
9.03 |
Main Test in Distilled Water
Table: Solubility in distilled water of the test item at different time intervals
Experiment |
A |
B |
C |
D (Blank) |
Amount of AE 1887196 [mg] |
23.8 |
18.6 |
19.6 |
- |
Stirring time at 30°C [h] |
24 |
48 |
72 |
72 |
pH at room temperature |
6.80 |
6.79 |
6.84 |
6.70 |
Water solubility [mg/L] |
39.9 |
39.1 |
43.7 |
- |
Table: Water Solubility of AE1887196
Solubility in |
Final pH |
CS Solubility at 20°C |
RSD |
distilled water |
6.81(1) |
41 mg/L |
6.0 % |
buffer pH 4 |
4.02(2) |
36 mg/L(2) |
- |
buffer pH 7 |
7.02(2) |
33 mg/L(2) |
- |
buffer pH 9 |
9.02(2) |
34 mg/L(2) |
- |
(1)resulting from 3 experiments
(2)results of the pretests
Description of key information
Pure grade: 41 mg/L (distilled water at pH 6.8 at 20°C), 33 – 36 mg/L (buffer solutions at pH 4-9 at 20 °C)
Key value for chemical safety assessment
- Water solubility:
- 41 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test item was determined by the flask method according to EU method A.6 and OECD Guideline 105.
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