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EC number: 216-407-3
CAS number: 1576-35-8
Summary of PCE/(PCE+NCE)
ratio and MNPCE frequency
No. of Animal
MNPCE per2,000 PCE
Vehicle(0.5 % methyl cellulose)
0.43 ( 0.11
0.67 ( 0.82
0.47 ( 0.04
0.47 ( 0.05
1.00 ( 0.89
0.45 ( 0.03
1.33 ( 0.82
75.50 ( 22.41*
*: Significant difference from the control at p < 0.01
MNPCE; Micronucleated polychromatic erythrocyte,
PCE; Polychromatic erythrocyte,
The genetic toxicity in vivo of OBSH was evaluated in a Mammalian
erythrocyte micronucleus test. The test was performed in accordance with
the OECD guideline 474.
All animals dosed with OBSH exhibited similar PCE/(PCE + NCE) ratios and
MNPCE frequencies compared to those of negative control animals (p >
0.01). All frequencies of MNPCE in the negative control groups fell
within acceptable ranges, while the positive control groups induced
clear increase in the frequencies of MNPCE.
It was concluded that OBSH did not induce micronuclei in the mice bone
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