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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Justification for type of information:
Read-across from acute dermal toxicity study on one closely structural and physicochemical related substance: OBSH (4,4'-Oxybis (benzenesulfonyl hydrazide)).
For further read-across justification se document attached in section 13.
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Reason / purpose:
read-across source
Reference
Endpoint:
acute toxicity: dermal
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:
Reason / purpose:
read-across source
Reference
Endpoint:
acute toxicity: dermal
Adequacy of study:
supporting study
Study period:
1950
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The original reference is not available. This study was not conducted according to GLP standard.
Reason / purpose:
reference to same study
Reference:
Composition 0
Qualifier:
according to
Guideline:
other: FIFRA Section 162.8 (c), March 1948
Deviations:
not specified
GLP compliance:
no
Limit test:
no
Test material information:
Composition 1
Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data
Type of coverage:
occlusive
Vehicle:
water
Details on dermal exposure:
The calculated dosage was first dissolved in distilled water and then placed onto gauze squares. The squares were immediately placed on the bare skin of each rabbit and securely held in place with waterproof adhesive tape. Care was taken to completely cover each patch securely so as to minimize evaporation and to insure continuous contact with the skin for 24 hours.
Duration of exposure:
24 hours
Doses:
200 mg/kg
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
no data
Statistics:
no data
Preliminary study:
NA
Mortality:
All animals were alive and well after the 24 hour period.
Clinical signs:
No toxic manifestations were exhibited by any of the animals under the test.
Body weight:
no data
Gross pathology:
no data
Other findings:
no data
Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The dermal acute toxicity of OBSH was evaluated in rabbit. The rabbits skin were in contact with a dose of 200mg/kg for 24 hours continuously.

The following observations were made after 24 hour exposure:
- All animals were alive and well after the 24 hour period
- No toxic manifestations were exhibited by any of the animals under the test.
Executive summary:

The dermal acute toxicity of OBSH was evaluated in rabbit. The rabbits skin were in contact with a dose of 200 mg/kg for 24 hours continuously.

The following observations were made after 24 hour exposure:

- All animals were alive and well after the 24 hour period

- No toxic manifestations were exhibited by any of the animals under the test.

Data source

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 200 mg/kg bw
Remarks on result:
not determinable due to absence of adverse toxic effects

Applicant's summary and conclusion

Executive summary:

No data is available for Toluene-4-sulphonohydrazide (T).

A dermal toxicity study (reliability score 4) is available using 200 mg/kg of OBSH. No effects were seen after 24 hours. The original reference is not available. This study was not conducted according to GLP standard. Further testing has not been planned. The acute dermal toxicity is not considered relevant as the relevant exposure routes to OBSH is considered to be oral and inhalation.

Due to the close chemical similarity to Toluene-4-sulphonohydrazide this value may be considered relevant for this substances as well.

See justification for read-across attached in section 13.