Registration Dossier
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EC number: 216-407-3 | CAS number: 1576-35-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- Read-across from acute dermal toxicity study on one closely structural and physicochemical related substance: OBSH (4,4'-Oxybis (benzenesulfonyl hydrazide)).
For further read-across justification se document attached in section 13.
Cross-referenceopen allclose all
- Reason / purpose:
- read-across source
Reference
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Reason / purpose:
- read-across source
Reference
- Endpoint:
- acute toxicity: dermal
- Adequacy of study:
- supporting study
- Study period:
- 1950
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The original reference is not available. This study was not conducted according to GLP standard.
- Reason / purpose:
- reference to same study
- Qualifier:
- according to
- Guideline:
- other: FIFRA Section 162.8 (c), March 1948
- Deviations:
- not specified
- GLP compliance:
- no
- Limit test:
- no
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- The calculated dosage was first dissolved in distilled water and then placed onto gauze squares. The squares were immediately placed on the bare skin of each rabbit and securely held in place with waterproof adhesive tape. Care was taken to completely cover each patch securely so as to minimize evaporation and to insure continuous contact with the skin for 24 hours.
- Duration of exposure:
- 24 hours
- Doses:
- 200 mg/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
- Preliminary study:
- NA
- Mortality:
- All animals were alive and well after the 24 hour period.
- Clinical signs:
- No toxic manifestations were exhibited by any of the animals under the test.
- Body weight:
- no data
- Gross pathology:
- no data
- Other findings:
- no data
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal acute toxicity of OBSH was evaluated in rabbit. The rabbits skin were in contact with a dose of 200mg/kg for 24 hours continuously.
The following observations were made after 24 hour exposure:
- All animals were alive and well after the 24 hour period
- No toxic manifestations were exhibited by any of the animals under the test. - Executive summary:
The dermal acute toxicity of OBSH was evaluated in rabbit. The rabbits skin were in contact with a dose of 200 mg/kg for 24 hours continuously.
The following observations were made after 24 hour exposure:
- All animals were alive and well after the 24 hour period
- No toxic manifestations were exhibited by any of the animals under the test.
Data source
Materials and methods
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Test material form:
- solid: particulate/powder
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 200 mg/kg bw
- Remarks on result:
- not determinable due to absence of adverse toxic effects
Applicant's summary and conclusion
- Executive summary:
No data is available for Toluene-4-sulphonohydrazide (T).
A dermal toxicity study (reliability score 4) is available using 200 mg/kg of OBSH. No effects were seen after 24 hours. The original reference is not available. This study was not conducted according to GLP standard. Further testing has not been planned. The acute dermal toxicity is not considered relevant as the relevant exposure routes to OBSH is considered to be oral and inhalation.
Due to the close chemical similarity to Toluene-4-sulphonohydrazide this value may be considered relevant for this substances as well.
See justification for read-across attached in section 13.
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