Toluene-4-sulphonohydrazide

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Justification for type of information:

Read-across from acute dermal toxicity study on one closely structural and physicochemical related substance: OBSH (4,4'-Oxybis (benzenesulfonyl hydrazide)).
For further read-across justification se document attached in section 13.

Cross-reference

Cross-reference 1

Reason / purpose:

read-across source

Reference

Endpoint:

acute toxicity: dermal

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Cross-reference 2

Reason / purpose:

read-across source

Reference

Endpoint:

acute toxicity: dermal

Adequacy of study:

supporting study

Study period:

1950

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: The original reference is not available. This study was not conducted according to GLP standard.

Reason / purpose:

reference to same study

Qualifier:

according to

Guideline:

other: FIFRA Section 162.8 (c), March 1948

Deviations:

not specified

GLP compliance:

no

Limit test:

no

Species:

rabbit

Strain:

not specified

Sex:

not specified

Details on test animals and environmental conditions:

No data

Type of coverage:

occlusive

Vehicle:

water

Details on dermal exposure:

The calculated dosage was first dissolved in distilled water and then placed onto gauze squares. The squares were immediately placed on the bare skin of each rabbit and securely held in place with waterproof adhesive tape. Care was taken to completely cover each patch securely so as to minimize evaporation and to insure continuous contact with the skin for 24 hours.

Duration of exposure:

24 hours

Doses:

200 mg/kg

No. of animals per sex per dose:

10

Control animals:

not specified

Details on study design:

no data

Statistics:

no data

Preliminary study:

NA

Mortality:

All animals were alive and well after the 24 hour period.

Clinical signs:

No toxic manifestations were exhibited by any of the animals under the test.

Body weight:

no data

Gross pathology:

no data

Other findings:

no data

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The dermal acute toxicity of OBSH was evaluated in rabbit. The rabbits skin were in contact with a dose of 200mg/kg for 24 hours continuously.

The following observations were made after 24 hour exposure:
- All animals were alive and well after the 24 hour period
- No toxic manifestations were exhibited by any of the animals under the test.

Executive summary:

The dermal acute toxicity of OBSH was evaluated in rabbit. The rabbits skin were in contact with a dose of 200 mg/kg for 24 hours continuously.

The following observations were made after 24 hour exposure:

- All animals were alive and well after the 24 hour period

- No toxic manifestations were exhibited by any of the animals under the test.

Materials and methods

Test material

Reference

Name:

Unnamed

Type:

Constituent

Test material form:

solid: particulate/powder

Results and discussion

Effect levels

Dose descriptor:

LD50

Effect level:

> 200 mg/kg bw

Remarks on result:

not determinable due to absence of adverse toxic effects

Applicant's summary and conclusion

Executive summary:

No data is available for Toluene-4-sulphonohydrazide (T).

A dermal toxicity study (reliability score 4) is available using 200 mg/kg of OBSH. No effects were seen after 24 hours. The original reference is not available. This study was not conducted according to GLP standard. Further testing has not been planned. The acute dermal toxicity is not considered relevant as the relevant exposure routes to OBSH is considered to be oral and inhalation.

Due to the close chemical similarity to Toluene-4-sulphonohydrazide this value may be considered relevant for this substances as well.

See justification for read-across attached in section 13.