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EC number: 216-407-3
CAS number: 1576-35-8
Cumulative immobilization of Daphnia magna
Cumuative no. of immobilized dahpnids
Symptoms of intoxication of the test item to Daphnia magna:
Symptoms of intoxication
(Unit: mg/L, time-weighted mean concentrations)
To assess the acute toxicity of toluene-4-sulphonohydrazide a study according to OECD Guideline No. 202 was conducted.
Range-finding test was conducted at the nominal concentrations of 0.1, 1, 10 and 100 mg/L by static system. No immobilization was observed in 0.1, 1 mg/L and 100% immobilization was observed in 10 and100 mg/L of test solution. . Therefore, the definitive test was performed with a control and nominal concentrations of 0.6, 1.3, 2.5, 5.0, 10 mg/L using a semi-static system. The definitive test was performed for 48 hours and 20 daphnids were exposed for each concentration with four replicates.
The time-weighted mean measured concentrations were 0.565, 1.12, 2.24, 4.33 and 8.45 mg/L (94.2, 86.2, 89.2, 86.6, 84.5 % of nominal concentration) for nominal concentrations of 0.6, 1.3, 2.5, 5.0 and 10 mg/L during test period.
During 48 hours of study period, no immobilization and toxic symptoms were observed in control, 0.6 and 1.3 mg/L of test solutions (time-weighted mean concentration: 0.565, 1.12 mg/L, respectively) and 20% immobilization was observed in 2.5 mg/L (time-weighted mean concentration: 2.24 mg/L). 100% immobilization (including dead) was observed in 5.0 and 10 mg/L of test solutions (time-weighted mean concentration: 4.33, 8.45 mg/L).
The 48hr-EC50 value (95% confidence limits) expressed in terms of the time-weighted mean concentration of toluene-4-sulphonohydrazide to Daphnia magna were determined to 2.71 mg/L (2.41-3.06 mg/L) and NOEC was 1.12 mg/L.mg/L) and NOEC was 1.12 mg/L.
To assess the acute toxicity of toluene-4-sulphonohydrazide a study according to OECD Guideline No. 202 was conducted. The 48hr-EC50 value (95% confidence limits) expressed in terms of the time-weighted mean concentration of toluene-4-sulphonohydrazide to Daphnia magna were determined to 2.71 mg/L (2.41-3.06 mg/L) and NOEC was 1.12 mg/L.mg/L) and NOEC was 1.12 mg/L.
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