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EC number: 216-407-3
CAS number: 1576-35-8
toxicokinetic data is available on p-TSH (T) and the primary read-across
substance OBSH (S1). As no specific data for the absorption rate from
the oral, the dermal or the inhalational route of exposure is available,
default assumption will be applied. Thus, absorption from dermal and
inhalational route is considered to be the same as for the oral route
In hydrolysis testing the hydrolysis of p-TSH into
toluene-4-sulphonic acid has been confirmed with T1/2 = 38.5 h (20 °C,
pH 7) and T1/2 = 139 h (20 °C, pH 4). The other metabolite is most
likely hydrazine (not specifically identified in the test) that may be
of concern due to its high toxicity. The hydrolysis half-life for the
source substance OBSH is considerable lower and thus the potential
toxicity of liberated hydrazine is expected to more expressed for OBSH
than for p-TSH. Also, the non-hydrolysed OBSH (containing two
arylsulphonylhydrazide units) is considered as a relevant read-across
substance for the non-hydrolysed p-TSH (a single
arylsulphonylhydrazide), due to the close structural similarity of the
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