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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

skin irritation: in vivo
Type of information:
Adequacy of study:
key study
2 (reliable with restrictions)
Justification for type of information:
No testing data on skin irriation is available for Toluene-4-sulphonohydrazide (TSH).
Use of Danish QSAR database and ToxTree; and classification of two pressumed breakdown products

Data source

Reference Type:
other: Q(SAR) prediction report
(Q)SAR predicted profile for toluene-4-sulphonohydrazide
Bibliographic source:
Danish Q(SAR) database
Report date:

Materials and methods

Principles of method if other than guideline:
in silico prediction models
- Danish QSAR database
- ToxTree (v3.1.0-1851-1525442531402)

Test material

Constituent 1
Chemical structure
Reference substance name:
EC Number:
EC Name:
Cas Number:
Molecular formula:
Test material form:
solid: particulate/powder

Results and discussion

In vivo

Irritation parameter:
other: QSAR prediciton
Remarks on result:
other: QSAR predicitons considered equivocal

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
it is considered appropriate to classify the substance as skin irrit.2
Executive summary:

No testing data on skin irritation is available for Toluene-4-sulphonohydrazide (TSH).

From QSAR predictions on skin irritation using the Danish QSAR database (see attached prediction report), only one out of three separate predictions from CASE Ultra, Leadscope and SciQSAR was considered valid (i.e., SciQSAR: Negative_ in scope). The leadscope had a positive prediction for skin irritation (out of scope) and the CASEultra had an inconclusive prediction for skin irritation. The overall prediction results for skin irritation are equivocal. Using the Toxtree programme, no alerts were identified for skin irritation.

Based on the overall dataset from different in silico prediction models (Danish QSAR database and ToxTree) no valid conclusion can be derived for skin irritation of TSH.

However, data from the presumed breakdown products of TSH can be used for the evaluation of the skin irritative potential of TSH. When applied to skin, TSH is expected to slowly hydrolyse due to the moisture in the skin with the presumed products being toluene-4-sulphonic acid (CAS No. 104-15-4) and hydrazine (CAS No. 302-01-2). This hydrolysis is though evaluated to be slow indicating that the concentration of the breakdown products also is low.

Toluene-4-sulphonic acid (CAS No. 104-15-4) has a harmonized classification for Skin Irrit. 2, H315. Furthermore, toluene-4-sulphonic acid is considered as skin corrosive since > 500 notifiers in the ECHA CLP database have classified the substance as Skin Corr. 1C.

Hydrazine (CAS No. 302-01-2) may be generated and could induce skin damage. Hydrazine, has a harmonized classification for Skin Corr. 1B.

Based on the skin irritation and corrosiveness of the two presumed breakdown products it is considered appropriate as a precautionary approach to classify TSH as skin irrit.2 here without further testing.