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EC number: 216-407-3
CAS number: 1576-35-8
Data from an acute inhalation toxicity study (OECD 436) is availabe, an LC50
> 5 mg/L was identified. Based on this result, no specific DNEL for
acute toxocity is considered necessary as the long-term DNEL would
sufficiently protect against high short term peak exposure as well.
p-TSH (T) and OBSH (S1) are both used as blowing agents in
industrial processing and for professional uses.
For systemic effects from long term inhalational exposure, no
inhalational study is available. A DNEL of 0.7 mg/m3 was established for
p-TSH based read-across from a NOAEL of 10 mg/kg bw/d from an oral OECD
408 90D study with OBSH (S1).
For local effects in respiratory tract from long term inhalational
exposure a DNEL of 0.1 mg/m3 is applicable based on a ACGIH TLV of 0.1
mg/m3 for OBSH (S1) derived to protect against effects from hydrazine
liberated from hydrolysis of OBSH (S1). Due to close structural
similarity to p-TSH (T) and a slower hydrolysis of p-TSH, a long term
inhalational exposure a DNEL of 0.1 mg/m3 is considered sufficient to
protect against peak concentrations of hydrazine for p-TSH as well.
For systemic effects from long term dermal exposure, no dermal
study is available. A DNEL of 0.1 mg/kg/d was established for p-TSH
based on read-across from a NOAEL of 10 mg/kg bw/d found in an oral OECD
408 90D study with OBSH (S1) in rats.
Short term exposure is controlled by conditions for long-term
exposure, therefore no DNEL has been established. Further, as OBSH (S1)
and p-TSH (T) has been identified as skin sensitizers, strict control
measures should apply.
No hazard can be identified for consumers and the general
population as exposure is considered neglible. p-TSH is used as a
blowing agent and during the foaming process, p-TSH decomposes into
nitrogen and toluene-4-sulphonic acid which is further degraded during
this process. Therefore, a direct consumer exposure is not likely to
occur since p-TSH is not contained in final products.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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