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EC number: 216-407-3
CAS number: 1576-35-8
p-TSH is used as blowing agents in industrial processing and for professional uses.
For systemic effects from long term inhalational exposure, no inhalational study is available. A DNEL of 0.09 mg/m3 was established for p-TSH based on NOAEL of 4 mg/kg bw/d from an oral OECD 422 study.
For local effects in respiratory tract from long term inhalational exposure a DNEL of 0.13 mg/m3 is applicable based on a ACGIH TLV of 0.13 mg/m3 for hydrazine to protect against effects from hydrazine liberated from hydrolysis of p-TSH.
For systemic effects from long term dermal exposure, no dermal study is available. A DNEL of 0.013 mg/kg/d was established for p-TSH based on a NOAEL of 4 mg/kg bw/d found in an oral OECD 422 in rats.
Short term exposure is controlled by conditions for long-term exposure, therefore no DNEL has been established. Further, as p-TSH has been identified as a skin sensitizer, strict control measures should apply.
No hazard can be identified for consumers and the general
population as exposure is considered neglible. p-TSH is used as a
blowing agent and during the foaming process, p-TSH decomposes into
nitrogen and toluene-4-sulphonic acid which is further degraded during
this process. Therefore, a direct consumer exposure is not likely to
occur since p-TSH is not contained in final products.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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