Registration Dossier
Registration Dossier
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EC number: 903-161-3 | CAS number: -
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The median effective loading rate of EC- 903-161-3 was estimated to be > 1000 mg / L ( the highest nominal loading rate) and the no-observed effect loading rate to be equal 1000 mg/L. These values were adjusted to account for the base oil solvent content of the sample tested (40.2%) , therefore EL50 of > 598 mg/L & NOELR of =598 mg/L is derived.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 598 mg/L
- EC10 or NOEC for microorganisms:
- 598 mg/L
Additional information
The study was designed to determine the effects of EC-903-161-3 on sewage treatment microorganisms by measuring the respiration rate under defined conditions. The study was conducted in accordance with the OECD 209 guidelines and GLP. The test was conducted with test solution prepared as Water Accommodated Fraction (WAF) at nominal loading rates of 10, 100 and 1000 mg/L.
Three replicates were included at the 1000 mg/L concentration to demonstrate that in the absence of inhibition, a definitive test is not necessary. A reference
item (3, 5-dichlorophenol) was tested as a reference inhibitory substance at the following nominal concentrations: 5, 15 and 30 mg/L along with duplicate untreated control vessels.
The test met guideline validity criteria as the coefficient of variation in control replicates was less than 30% and the EC50 (3 h) for the reference item was in the range 2 to 25 mg/L.
Respiration was not inhibited at 10, 100 or 1000 mg EC-903-161-3/L. The median effective concentration (EC50) of EC-903-161-3, i.e. the concentration which causes a 50% reduction in respiration rate in activated sludge, was estimated to be >1000 mg EC-903-161-3 /L and the no-observed effect loading rate (NOELR) to be equal 1000 mg/L. This was adjusted for the presence of oil.
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