Registration Dossier
Registration Dossier
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EC number: 903-161-3 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The 96-hour 50% Lethal Loading rate (LL50) value was > l000 mg/L (the highest loading rate tested) based on exposure to the WAF of the test substance. This value was adjusted to account for the base oil solvent content of the sample tested (40.2%) , therefore a LL50 value of > 598 mg/L is derived as a key value for any assessment. There were no mortalities and no sub-lethal effects in 10 fish exposed to 1000 mg/L loading rate WAF for a period of 96 hours.This result on the analogue material is considered to be appropriate for the Registration substance.
Key value for chemical safety assessment
Additional information
The comparison of overall physicochemical and toxicity profiles for tested and analogue materials indicate it is appropriate to apply read-across data from the structural surrogate when considering the acute aquatic toxicity data (see detailed read-across justification in IUCLID section 13).
The study was performed to determine the acute toxicity of water accommodated fractions (WAF) of the analogue test substance to rainbow trout, Oncorhynchus mykiss in a semi-static system for a 96-hour period. Water Accommodated Fractions prepared at the following loading rates were tested; l000 mg/L and l00 mg/L. Laboratory dilution water (BW3) was used as a control. Two replicate chambers per loading rate were tested. Daily renewals were performed by siphoning approximately 80% of the WAF from each test chamber and refilling with fresh WAF to the original volume. Samples were taken on Day 0, 1, 2 and 3 ("new" solution) and Day 1 and 4 ("old" solution) and analysed for Total Organic Carbon (TOC). The results of the TOC analysis indicated that the concentration of total organic carbon in the WAFs was below the minimum quantitation limit of 1 ppm. The 96-hour 50% Lethal Loading rate (LL50) value was > l000 mg/L (the highest loading rate tested). There were no mortalities and no sub-lethal effects in 10 fish exposed to 1000 mg/L loading rate WAF for a period of 96 hours.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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