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EC number: 220-479-1
CAS number: 2781-00-2
The scores recorded for cornea and iris were zero (0) in all
rabbits at all reading times. A maximum score of 2 (slight
to moderate) for redness and 2 (slight to moderate swelling)
for chemosis were observed in 2/3 rabbits after 1 hour. At
24 hours only 1/3 rabbits still had a score of 2 for
redness, all other scores were 1 or 0. 2/3animals had a
score of 1 for redness, and 1/3 had a score of 1 for
chemosis at 48 hours. At 72 hours all scores were zero (0).
The laboratory stated that the test material was not an eye
irritant based upon the EEC standards for evaluation.
The potential of the
peroxide to induce ocular irritation was evaluated in rabbits according
to OECD405 guideline.
The substance was
administered to three male New Zealand White rabbits.
A single dose of 0.1 g
of the substance was instilled into the left/right conjunctival sac. The
right/left eye was not treated and served as control. The eyes were not
rinsed after administration of the test item.
Ocular reactions were
observed approximately 1 hour, 24, 48 and 72 hours after the
administration of the test substance. The mean values of the scores for
chemosis, redness of the conjunctiva, iris lesions and corneal opacity
were calculated for each animal.
After one hour, the
eyes effects observed in all rabbits consisted of slight or moderate
redness and slight or moderate swelling of the consjunctivae. All these
clinical signs were fully reversible within 72 hours.
Mean scores calculated
for each animal over 24, 48 and 72 hours were (0) (0.6) and (0) for
chemosis, (0.3) (1) and (0.6) for redness of the conjunctiva, (0) (0)
and (0) for iris lesions and (0) (0) and (0) for corneal opacity.
experimental conditions, the test item was considered as sligh irritant
when administered by ocular route to rabbits.
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