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EC number: 220-479-1
CAS number: 2781-00-2
The acute oral toxicity of the test item, 1,3(4)‑bis(tert-butylperoxyisopropyl)benzene
(batch No. 307090713), was evaluated in rats according to OECD
17th December 2001) and Commission
Regulation (EC) (No. 440/2008, B.1tris, 30 May 2008) guidelines.
study was conducted in compliance with the principles of Good Laboratory
The test item was prepared in 0.5%
methylcellulose and was administered by oral route (gavage), under a
volume of 10 mL/kg, to groups of three fasted female Sprague-Dawley rats.
The study design was as follows:
Clinical signs, mortality and body
weight gain were checked for a period of up to 14 days following the
single administration of the test item.
Neither mortality nor clinical signs
were observed during the study.
When compared to CIT historical
control data, a lower body weigh gain was noted in 2/6 animals (6 and
8 g vs. 17 ± 8 g in historical data base) between day 8 and
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