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EC number: 220-479-1
CAS number: 2781-00-2
There is no data on
1,4-bis[1-(tert-butylperoxy)-1-methylethyl]benzene. A read across
approach is proposed with 1,3 (or
The in vitro rate
of metabolism was determined for [1,3(or 1,4)-
Phenylenebis(1-methylethylidene)] bis[tert-butyl] peroxide using the in
vitro metabolism trout liver S9 essay (this approach is not yet an
established guideline and is still being developed. Nevertheless, the
general approach appears to be scientifically valid and is under
development by the Bioconcentration Working Group of ILSI/HES).
This organic peroxide
metabolized rapidly under biologically active conditions with a
metabolic half- life of 67 minutes or 1.13 hours. This data was used to
extrapolate in vivo rate constants of metabolism or kMET of
0.184 day-1 or 0.475 day-1 using hepatic portal
blood flow or hepatic portal and arterial blood flow, respectively. The
use of these kMET values
in conjunction with the Gobas model dropped the calculated BCF from
45,294 kg day-1 (assuming no metabolism) to 536 or 209 kg day-1.
The impact of metabolism on [1,3(or 1,4)-
Phenylenebis(1-methylethylidene)] bis[tert-butyl] peroxide drops the BCF
to less than the action level of 2000 (Reach Criteria) and should not be
considered to have significant bioaccumulation potential.
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