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EC number: 220-479-1
CAS number: 2781-00-2
1,4-bis(tert-butylperoxyisopropyl)benzene has no effect at a 100% v/v saturated solution (100 mg/L).
acute toxicity of 1,4-bis(tert-butylperoxyisopropyl)benzene to zebra
fish has been investigated according to OECD 203 guideline in a GLP
study. As no effect was observed during the preliminary test, a
definitive limit-test at 100 mg/L was conducted and gave a 96-Hour LC50
of greater than 100% v/v saturated solution. The No Observed Effect
Concentration was 100% v/v saturated solution.
To conclude, this study showed no
toxic effects at saturation.
This study was performed in order to
confirm the Read-Across approach between
1,3-bis[1-(tert-butylperoxy)-1-methylethyl]benzene (see document
attached to IUCLID) for which no effect was also observed with a similar
study (summary below):
was tested in an acute toxicity test with Poecilia reticulata (guppy)
under semi-static conditions in accordance with EEC method C.1. (1984)
and OECD Test Guideline 203 (1984). At all concentrations tested the
fish developed serious deviations in behaviour and appearance during the
test period, such as reduced activity, convulsive movements and floating
on the back. Most of the fish developed a thick white stomach.
After 96 hours, no mortality was
observed up to and including 560 mg/L and 100% mortality was observed at
1000 mg/L after 96 hours and at1800 mg/L after 24 hours.
The LC50(96 h) was
calculated to be 750 mg/L, with 95% confidence limits of 360 and 1570
However, given that during the test a
layer of test substance remained visible on the surface of the test
media in all test concentrations, the LC50value should be
handled with care. Moreover no analytical monitoring was performed
during the test. Based upon the fact that no mortality was observed this
test can be considered as valid with restrictions.
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