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EC number: 220-479-1
CAS number: 2781-00-2
The acute dermal toxicity of Perximon F ( 1,3 &
1,4-di-(2-t-butylperoxyisolpropyl)benzene) was evaluated in rats
according to OECD N° 402 guideline and EC 92/69/EEC B.3 guidelines
(Acute Toxic Standard Method). Peroximon F was applied to the skin of
groups of 5 male and 5 female Sprague Dawley rats at doses of 2000 mg/kg
in a semi-occlusive dressing for 24 hours. Following treatment, rats
were observed daily and weighted weekly. A gross necropsy examination
was performed at the time of scheduled euthanasia (Day 14).
No mortality and no abnormal clinical signs were observed. Only a slight
bodyweight loss was seen in 4/5 females between day 1 and day 8. At
necropsy, no abnormal gross pathology was observed.
Under these experimental conditions, the dermal LD50 of Peroximon F is
assumed to be more than 2000 mg/kg in Sprague Dawley rats.
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