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EC number: 220-479-1
CAS number: 2781-00-2
a fish study which was performed in order to confirm the Read-Across
approach between 1,4-bis(tert-butylperoxyisopropyl)benzene and
1,3-bis[1-(tert-butylperoxy)-1-methylethyl]benzene (see document
attached to IUCLID), there is no data on
on this read-across, one key study is available for each of the
term Toxicity to Fish:
acute toxicity of 1,4-bis(tert-butylperoxyisopropyl)benzene to zebra
fish has been investigated according to OECD 203 guideline in a GLP
study. As no effect was observed during the preliminary test, a
definitive limit-test at 100 mg/L was conducted and gave a 96-Hour LC50
of greater than 100% v/v saturated solution. The No Observed Effect
Concentration was 100% v/v saturated solution. To conclude, this study
showed no toxic effects at saturation.
term Toxicity to Aquatic invertebrates:
1,4)-Phenylenebis(1-methylethylidene)]bis[tert-butyl]peroxide was not
found to be acutely toxic to Daphnia magna when dispersed in
water at a nominal loading rate of 1.0 mg/L equivalent to an initial
mean measured concentration of 0.0219 mg/L. Consequently, the 48-hour
EC50 value for [1,3(or
1,4)-Phenylenebis(1-methylethylidene)]bis[tert-butyl]peroxide could not
be calculated but must be >1.0 mg/L (>0.0219 mg/L). The “no observed
effect loading rate” was 1.0 mg/L (0.0219 mg/L as initial mean measured
term Toxicity to freshwater algae:
acute toxicity of [1,3(or
1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide was
evaluated with Pseudokirschneriella subcapitata in a study
performed in accordance with OECD testing guideline 201 and GLP
algae were exposed to nominal test concentrations of 1 mg/L under static
conditions during 72 hours. The mean measured concentrations were not
maintained between 80 and 120 % of nominal. The test substance was not
found to be acutely toxic to Pseudokirchneriella subcapitata at a
nominal loading rate of 1.0 mg/L, equivalent to an initial mean measured
concentration of 0.0471 mg/L.
in order to predict effects of chemicals in the environment and in
biological wastewater treatment plants, an activated sludge respiration
inhibition test was performed on
1,3-bis[1-(tert-butylperoxy)-1-methylethyl]benzene according to OECD 209
guideline and GLP requirements. The test substance was not soluble in
water and therefore the activated sludge was exposed to bis (tert-butyl
peroxy isopropyl)benzene adsorbed onto silica gel at a concentration of
1 g/L. By this exposure no effect was recorded indicating that the
obtained distribution of 1,3-bis[1-(tert-butylperoxy)
-1-methylethyl]benzene in the water system did not inhibit the activated
summarize, no effect of 1,4-bis(tert-butylperoxyisopropyl)benzene was
observed up to its water solubility limit.
According to claimed uses of
1,4-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide aquatic
compartment exposure is likely. At the moment no data is available for
peroxide long-term effects on organisms inhabiting aquatic compartment.
Risk assessment demonstrated that there is no risk for those organisms
using the PNEC derived based upon acute data, however a long-term test
on aquatic invertebrates was proposed with an analogous substance (CAS
25155-25-3). As soon as this test on CAS 25155-25-3 is available, the
REACH dossier will be updated.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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