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EC number: 800-172-4
CAS number: 398141-87-2
7.4.1/1: Individual challenge data
purposes of calculation, ± = 0.5;
a Guinea Pigs-Modified Buehler test performed according to OECD
Guideline 406 and in compliance with GLP.
The dermal sensitization potential
of the test material was evaluated in Hartley-derived albino guinea
pigs. Ten male and ten female guinea pigs were topically treated with
100% test material, once per week, for three consecutive weeks. Following
a two-week rest period, a challenge was performed whereby the 20 test
and 10 previously untreated (naive) challenge control guinea pigs were
topically treated with 100% test material. Challenge responses in the
test animals were compared with those of the challenge control animals.
Following challenge with 100% test
material, dermal reactions in the test and challenge control animals
were limited to scores of 0 to ±. Group mean dermal scores were noted to
be similar in the test animals as compared to the challenge control
Using a-Hexylcinnamaldehyde (HCA)
as a positive control, Charles River Laboratories, Inc., Spencerville,
Ohio, has completed a study during the past six months which provided
historical control data for contact sensitization to this agent
utilizing the test system described herein (Modified Buehler Design).
Following induction at 5% w/v HCA in ethanol, challenge at levels of
2.5% and 1% w/v HCA in acetone and rechallenge at a level of 2.5% w/v
HCA in acetone, a contact sensitization response was observed, thereby
demonstrating the susceptibility of the test system to this sensitizing
Number of Test Animals with Score
> 1/Number Dosed
challenge control animals had scores of ± and 0.
The test substance is not
sensitizing under these test conditions.
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