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EC number: 205-289-9
CAS number: 137-32-6
48 hours after administration of the test material, no significant
increase in the micronucleus frequency has been detected in the main
study as compared to the negative control group. 24 hours after start of
the treatment, no increase in the micronucleus frequency was seen in the
male group either. Micronucleus frequency of the 24 hour female group
was weakly (0.17 % cells with micronuclei, negative control: 0.05 %) and
statistically significantly (p = 0.02) increased.
The obtained mean numbers of polychromatic erythrocytes with micronuclei
per 1000 PCE (MN-PCE) are presented below:
MN-PCE (%) in males
MN-PCE (%) in females
For the number of normochromatic cells with micronuclei, no increase was
Since the observed positive effect in the female animals (24 hrs) was
only minimal, it was considered to be not relevant.
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