Registration Dossier
Registration Dossier
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EC number: 205-289-9 | CAS number: 137-32-6
Endpoint summary
Administrative data
Description of key information
Additional information
Aquatic toxicity
Short-term toxicity to fish
The acute toxicity of the test substance 2-methylbutan-1-ol to Zebrafish (Danio rerio) was assessed according to OECD 203 under GLP conditions in a semi-static system (BASF SE, 17F0340/10E022, 2011). The 96 hour LC50 was determined to be nominal greater than 120 mg/L.
Long-term toxicity to fish
In Annex IX of Regulation (EC) No 1907/2006, it is laid down that long-term toxicity testing shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further the effects on aquatic organisms. According to Annex I of this regulation, the chemical safety assessment triggers further action when the substance or the preparation meets the criteria for classification as dangerous according to Directive 67/548/EEC or Directive 1999/45/EC or is assessed to be a PBT or vPvB. The hazard assessment of 2-methylbutan-1-ol reveals neither a need to classify the substance as dangerous for the environment, nor is it a PBT or vPvB substance, nor are there any further indications that the substance may be hazardous to the environment. Therefore, and for reasons of animal welfare, a long-term toxicity study in fish is not provided.
Short-term toxicity to aquatic invertebrates
The acute toxicity of the test substance 2-methylbutan-1-ol on aquatic invertebrates was investigated under GLP conditions according to OECD 202. The 48h-EC50 value was determined to be greater than 173 mg/L (value based on measured concentration).
Long-term toxicity to aquatic invertebrates
In Annex IX of Regulation (EC) No 1907/2006, it is laid down that long-term toxicity testing shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further the effects on aquatic organisms.
According to Annex I of this regulation, the chemical safety assessment triggers further action when the substance or the preparation meets the criteria for classification as dangerous according to Directive 67/548/EEC or Directive 1999/45/EC or is assessed to be a PBT or vPvB.
The hazard assessment of 2-methylbutan-1-ol reveals neither a need to classify the substance as dangerous for the environment, nor is it a PBT or vPvB substance, nor are there any further indications that the substance may be hazardous to the environment. Therefore a long-term toxicity study in aquatic invertebrates is not provided.
Toxicity to algae and cyanobacteria
The toxicity of the test substance to the freshwater alga Pseudokirchneriella subcapitata was determined also according to the principles of OECD 201 under GLP conditions. After 72 hours the NOEC was determined to be 29 mg/L, the ErC10 was determined to be 132 mg/L and the ErC50 was determined to be greater than 353 mg/L. All values based on measured concentrations.
Toxicity to aquatic plants other than algae
Data on toxictiy to aquatic plant other than algae are not required for REACh registration.
Toxicity to microorganisms
A study according to OECD 209 (BASF 2010) was performed to determine the toxic effects of the test substance 2-methylbutan-1-ol (CAS 137-32-6) on the oxygen consumption rate of aerobic micro-organisms (activated sludge) after 180 min. The EC50 was determined to be greater than 1000 mg/L and the EC10 was determined to be 470 mg/L.
Toxicity to other aquatic organisms
No requirement under REACh
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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