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EC number: 205-289-9
CAS number: 137-32-6
Sensitisation dataThe test substance itself as well as other category members were found to not be skin sensitising.Exposure related observationsThe nasal pungency threshold of the read-across substance pentan-1-ol was found to be 5.86 mg/L.A member of the category was found to be irritating to the throat at a concentration of 0.366 mg/L.The read-across substance pentan-1-ol was not irritating to the skin of 30 human volunteers.
Sensitisation data (humans)
Data are available obtained in a human
maximization test conducted with 3-methylbutan-1-ol (Kligman 1976). In
this study, the sensitization to skin was evaluated in 25 human
volunteers, who received an application of 8 % 3-methylbutan-1-ol in a
2.5 % aqueous sodium lauryl sulfate solution. The substance was applied
via an occlusive patch test to the same site on the volar forearm or
back of all subjects for five alternate-day 48 hour periods. Evaluation
of the skin sites revealed that none of the 25 individuals showed any
signs of sensitization.
Furthermore, publications are available
describing the sensitisation potential of 2-methylbutan-1-ol or the
read-across substance pentan-1-ol. These studies were included for
completeness sake, but it has to be mentioned that the human volunteers
described in the publications had been exhibiting dermatitis or skin
reactions towards other alcohols before.
In an epicutaneous patch test (Fregert 1963)
one volunteer was exposed to 2-methylbutan-1-ol and pentan-1-ol
(separate applications) at a concentration of 10 %. Positive skin
reactions were found, but the test person had already been exhibiting
dermatitis before. In another publication four test persons, also
exhibiting dermatitis and positive skin reactions to ethanol, were
tested and positive skin reactions were also revealed when testing
3-methylbutan-1-ol or pentan-1-ol (Fregert 1969). A further test person
who showed positive skin reactions towards hair lotions was exposed to a
series of lower aliphatic alcohols and also to pentan-1-ol in an
epicutaneous patch test (Ludwig 1977). No positive skin reactions were
revealed for pentan-1-ol.
In another publication two volunteers who
had been tested positive for ethanol and acetaldehyde, respectively,
were also exhibiting positive skin reactions when exposed to pentan-1-ol
at 10 % and 20 % (Stotts 1977).
Exposure related observations in humans:
In a publication (Nelson 1943) the irritant
property of 3-methylbutan-1-ol to the throat was investigated. The
concentration at which the vapour caused irritation to the throat was
determined to be 100 ppm (corresponding to 0.366 mg/L).
In a further publication (Cometto-Muniz
1990) a study is described which was conducted to assess the odor
threshold of 11 chemicals including pentan-1-ol. The detection
thresholds were measured repeatedly in normosmic and anosmic subjects.
The stimuli comprised the first eight members of the series of
n-aliphatic alcohols, phenyl ethyl alcohol, pyridine and menthol. The
anosmic subjects were: one male (39 -years-old, nonsmoker, congenital
anosmic) and two females (a 35-year-old, nonsmoker, head-trauma anosmic
and a 20-year-old, smoker, congenital anosmic).Sessions typically lasted
between two and four hours, and they were repeated until 12 thresholds.
Recalculation of vapour concentration was performed according to the
formula: C (mg/m3) = (molecular weight (g) * C (ppm)) / 24.1 L at 20°C
and 1013 hPa (DFG, MAK-Liste).The test substance was detected by all
subjects. The average nasal pungency threshold was found to be (± SD):
1603 ± 1.2 ppm equivalent to 5.86 mg/L.
Furthermore, a study report is available
evaluating the potential of pentan-1-ol to induce skin irritation. 30
human volunteers was used to apply 0.2 mL of pentan-1-ol on a 25 mm
plain Hill Top Chamber containing a Webril pad to the skin of the upper
outer arm (Basketter et al. 2004). After an application of 15 and 30
minutes through 1, 2, 3 and 4 hours, pentan-1-ol was found to be not
irritating to skin.
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