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EC number: 205-289-9 | CAS number: 137-32-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Internal BASF method was used which was in large part equivalent to OECD guideline 401
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-methylbutan-1-ol
- EC Number:
- 205-289-9
- EC Name:
- 2-methylbutan-1-ol
- Cas Number:
- 137-32-6
- Molecular formula:
- C5H12O
- IUPAC Name:
- 2-methylbutan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): 2-methylbutanol-1
- Physical state: liquid
- Analytical purity: ca. 99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: mean 220 g (males), 170 g (females)
- Fasting period before study: 15 - 20 hours
- Diet: Herilan MRH-Haltung; H Eggersmann KG; ad libitum
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 14.7, 21.5, 31.6, 50%
- Amount of vehicle (if gavage): 10 ml/kg bw - Doses:
- 1470, 2150, 3160, 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily recording of signs and symptoms from the day of administration till the end of the observation period. Daily check (twice) for moribund and dead animals (once during the weekend).
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, pathology. - Statistics:
- Chi-Square analysis
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 172 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 3 501 - 5 060
- Mortality:
- 5000 mg/kg bw: 2/5 males within 1 h; 3/5 males within 1 d; 4/5 females within 1 h; 5/5 females within 1 d
3160 mg/kg bw: 1/5 females within 1 d - Clinical signs:
- other: See table 1
- Gross pathology:
- Surviving animals: nothing abnormal detected; dead animals: acute congestive hyperemia in the heart and cardiodilatation.
Any other information on results incl. tables
Table 1: Clinical signs
Time of occurrence in minutes (min), hours (h) or days (d) |
||||
Dose level |
5000 (mg/kg bw) |
3160 (mg/kg bw) |
2150 (mg/kg bw) |
1470 (mg/kg bw) |
Symptoms |
||||
Dyspnea – shallow respiration |
15 min–3 d |
15 min–5 h |
15 min–5 h |
15 min–1 h |
Stertorous respiration |
3-7 d |
- |
- |
- |
Apathy |
15 min–6 d |
15 min–5 h |
15 min–5 h |
15 min–1 h |
Abnormal/lateral position |
15 min–5 h |
15 min–5 h |
15 min–5 h |
15 min–30 min |
Staggering |
15 min–3 d |
15 min–5 h |
15 min–5 h |
15 min–1 h |
Paresis/ Atonia |
15 min–5 h |
15 min–5 h |
15 min–5 h |
- |
Pain/ Corneal reflex absent |
15 min–1 h |
15 min–5 h |
15 min–5 h |
- |
Narcotic-like state |
15 min–1 h |
15 min–5 h |
15 min–5 h |
- |
Piloerection/ Erythema |
15 min–7 d |
4 h–5 d |
- |
- |
Poor general state |
15 min–6 d |
15 min–5 h |
15 min–5 h |
- |
Table 2: Body weight
Mean body weight of survival animals (g); M: male; F: female |
||||||||
Dose level (mg/kg bw) |
5000 |
3160 |
2150 |
1470 |
||||
Time after treatment |
M |
F |
M |
F |
M |
F |
M |
F |
0 |
260 |
170 |
200 |
180 |
200 |
180 |
200 |
180 |
2-3 |
248 |
- |
228 |
199 |
235 |
199 |
213 |
199 |
7 |
273 |
- |
254 |
213 |
266 |
213 |
259 |
211 |
13 |
303 |
- |
287 |
217 |
297 |
224 |
272 |
221 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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