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EC number: 205-289-9
CAS number: 137-32-6
The acute toxicity of the test substance 2-methylbutan-1-ol on aquatic invertebrates was investigated under GLP conditions according to OECD 202. The 48h-EC50 value was determined to be greater than 173 mg/L (value based on measured concentration).
The acute toxicity of the test
substance 2-methylbutan-1-ol on aquatic invertebrates was investigated
under GLP conditions according to OECD 202. The nominal test
concentration was 120 mg/L and the mean measured concentration was
determined to be 173 mg/L. The study encompassed 4 replicates per
concentration and 4 replicates per control. The number of the organisms
per vessel was 5. The pH and oxygen content were measured at the start
of the exposure and at the end of the exposure in replicate 1 of all
test concentrations and the control. Temperature was measured
continuously during the whole period in a separate vessel. The mobility
of the Daphnia was determined after 0, 24 and 48 hours. The 48h-EC50
value was determined to be greater than 173 mg/L (value based on
In addition the short-term toxicity to
aquatic invertebrates of the other category members was assessed.
In the acute immobilization test with
Daphnia magna (STRAUS), the effects of the surrogate test substance
pentan-1-ol were determined according to Regulation (EC) No 79/831/C2
under non GLP conditions. The mobility of the Daphnia was determined in
a static 48-hour test by visual observation after 3, 6, 24 and 48 hours.
The 48h-EC50 value was determined to be nominal 341 mg test item/L.
Supplementary the acute toxicity of
the surrogate test substance 3-methylbutan-1-ol to Daphnia magna was
assessed according to DIN 38412 L11. The 48 h-EC50 value was determined
to be nominal 255 mg test item/L.
Study results are also available for
the fourth category member pentanol, branchend and linear. The EC50
value of this substance was determined to be greater than 120 mg/L in a
GLP guideline study with Daphnia magna according to OECD 202.
In conclusion the 48h-EC50 value of
the test substance and of the read across category members was
determined to be greater than 100 mg/L. As the EC50 value determined
with the read-across substance 3-methylbutan-1-ol was lower than the
EC50 value determined in the study with the target substance itself, the
smaller value was chosen as “key value” and also used for PNEC
derivation, reflecting a worst case scenario.
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