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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
short-term repeated dose toxicity: other route
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication which meets basic scientific principles For justification of read-across please refer to section 13.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Test for carcinogenicity of food additives and chemotherapeutic agents by the pulmonary tumor response in strain A mice
Author:
Stoner GD et al.
Year:
1973
Bibliographic source:
Cancer Research 33, 3069-3085
Reference Type:
secondary source
Title:
No information
Author:
RIFM
Year:
2009
Bibliographic source:
RIFM database

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
preliminary toxicity study for a following carcinogenicity study
GLP compliance:
no
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Pentan-1-ol
EC Number:
200-752-1
EC Name:
Pentan-1-ol
Cas Number:
71-41-0
Molecular formula:
C5H12O
IUPAC Name:
pentan-1-ol
Details on test material:
- Lot/batch No.: Lot 36176
- Source: J.T. Baker Chemical Co., Phillipsburg, NJ

Test animals

Species:
mouse
Strain:
other: A/He
Sex:
female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Institute for Cancer Research, Philadelphia, or obtained from the National Cancer Institute
- Age at study initiation: 6 - 8 w
- Weight at study initiation: 18 - 20 g
- Housing: in groups of 5 in plastic boxes
- Diet (e.g. ad libitum): Purina laboratory chow; ad libitum
- Water (e.g. ad libitum): water; ad libitum

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: tricaprylin
Analytical verification of doses or concentrations:
no
Duration of treatment / exposure:
2 weeks
Frequency of treatment:
6 times in 2 weeks
Doses / concentrations
Remarks:
Doses / Concentrations:
50, 250 mg/kg/bw (nominal conc. dose per application)
No. of animals per sex per dose:
5
Control animals:
yes, concurrent no treatment
yes, concurrent vehicle
Details on study design:
- Post-exposure period: 1 - 2 months
- The MTD was the maximum single dose that all 5 mice tolerated after receiving 6 i.p, injections over a 2-week period.

Results and discussion

Effect levels

Dose descriptor:
other: MTD
Effect level:
6 000 mg/kg bw (total dose)
Based on:
test mat.
Sex:
female

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion