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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication which meets basic scientific principles For justification of read across please refer to section 13.

Data source

Reference
Reference Type:
publication
Title:
Formation of esterified fatty acids in rats administered 1-Butanol and 1-Pentanol
Author:
Carlson GP
Year:
1994
Bibliographic source:
Research Communications in Molecular Patholog and Pharmacology, 86(1), 111-117

Materials and methods

Objective of study:
metabolism
Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Pentan-1-ol
EC Number:
200-752-1
EC Name:
Pentan-1-ol
Cas Number:
71-41-0
Molecular formula:
C5H12O
IUPAC Name:
pentan-1-ol
Details on test material:
- Name of test material (as cited in study report): 1-Pentanol
Radiolabelling:
no

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Harlan Sprague-Dawley, Indianapolis, IN
- Diet (e.g. ad libitum): Purina Rodent Chow (Purina Mills, St. Louis, MO); ad libitum
- Water (e.g. ad libitum): water; ad libitum


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C
- Photoperiod (hrs dark / hrs light): 12 / 12

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: Emulphor 620:water (1:18)
Duration and frequency of treatment / exposure:
one application
Doses / concentrations
Remarks:
Doses / Concentrations:
0.25 ml/kg bw
No. of animals per sex per dose / concentration:
no data
Control animals:
not specified
Details on dosing and sampling:
PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled liver, in some cases pancreata and lungs
- Time and frequency of sampling: 1 h after dosing

Results and discussion

Metabolite characterisation studies

Metabolites identified:
no
Details on metabolites:
No pentyl esters were found that cochromatographed with the standards in the gas chromatographic analysis in preparations of any of the tissues, pancreas, lung or liver.
In addition, gas chromatography - mass spectrometry was also unable to identify any pentyl esters of fatty acids in liver or lung extracts.

Any other information on results incl. tables

The esterification of fatty acids by ethanol via a
nonoxidative pathway has been well documented and has been
implicated in toxic effects in animals and humans.
The administration of 1-pentanol (0.25 ml/kg; i.p.; male SD
rats) did not result in esterification of fatty acids.
According to the authors these data suggest that chain
length may be important in the ability of alcohols to
esterify fatty acids in vivo.

Applicant's summary and conclusion

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