Registration Dossier
Registration Dossier
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EC number: 442-070-9 | CAS number: 329039-38-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The cutaneous allergenic potential of methyldiacetoxyisopropoxy silane was investigated by the GPMT. The study was performed in male and female albino guinea pigs in accordance with OECD Guideline No. 406. No abnormal symptoms and overt toxicity were observed in all animals at the 24- and 48-hour reading after treatment with the test item at 100% in cotton seed oil. Also no skin effect was observed in the control group. Based on the findings of this adjuvant sensitization test methyldiacetoxyisopropoxy silane is regarded to have no skin sensitising properties.
Migrated from Short description of key information:
Skin: not sensitising (Lister, 2001)
Justification for classification or non-classification
According to DSD (67/548/EEC) and CLP (1272/2008/EC) methyldiacetoxyisopropoxy silane does not meet the criteria to be classified regarding this endpoint.
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