Registration Dossier
Registration Dossier
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EC number: 442-070-9 | CAS number: 329039-38-5
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (48 h) > 1000 mg/L (nominal)(Daphnia magna)
Key value for chemical safety assessment
Additional information
The acute toxicity of methyldiacetoxyisopropoxy silane (CAS No. 329039-38-5) to aquatic invertebrates was investigated in a study by Eickhoff (2002), using Daphnia magna as test species. This test was conducted according to OECD Guideline 202 (Daphnia sp., Immobilization test) under GLP conditions. Daphnids were exposed to the test substance for 48 hours at 20 ± 1 °C. The concentration of isopropanol (hydrolysis product) was determined by means of GC. No immobilisation was observed at any of the concentrations tested (440-1000 mg/L) and therefore the 48h-EC50 was determined to be > 1000 mg/L (based on initial nominal test substance concentrations). Acute invertebrate toxicity data from acetic acid were found to range from 65-6000 mg/L (depending on pH neutralized or un-neutralized solutions, EC50 values (48 h), OECD SIDS for analogue substance Methyltriacetoxysilane (CAS No. 4253-34-3), 2005), whereas EC(L)50 values for isopropanol ranged from 1400 to > 10000 mg/L (OECD SIDS, 1997).
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